ArticleJournal of assisted reproduction and genetics2018
Improvement of pregnancy outcome by extending embryo culture in IVF-ET during clinical application.
Article in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Different effectiveness of acupuncture treatment schedule on ART pregnancy outcomes: a systematic review and network meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Commentary: Association between pretransfer cleavage-stage blastomere dynamics and pregnancy outcomes in fresh single embryo transfer cycles: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Nomogram to predict FSH starting dose in poor ovarian response women in progestin primed ovarian stimulation protocol.BMC women's health · 2023Article
- Clinical Application of Double Ovulation Stimulation in Patients with Diminished Ovarian Reserve and Asynchronous Follicular Development Undergoing Assisted Reproduction Technology.Current medical science · 2023Article
- DTLR-CS: Deep tensor low rank channel cross fusion neural network for reproductive cell segmentation.PloS one · 2023Article
- Dynamics and clinical relevance of maternal mRNA clearance during the oocyte-to-embryo transition in humans.Nature communications · 2020Article
- Pre-Implantation Mouse Embryos Cultured In Vitro under Different Oxygen Concentrations Show Altered Ultrastructures.International journal of environmental research and public health · 2020Article
- Establishment of predictive model for analyzing clinical pregnancy outcome based on IVF-ET and ICSI assisted reproductive technology.Saudi journal of biological sciences · 2020Article
- Impact of Previous-day versus Same-day Warming of Cleavage-stage Embryos on Reproductive Outcomes: A Retrospective Cohort Study.Journal of human reproductive sciencesArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeThe purpose of this study is to investigate the application value of the extended embryo culture for 7-8 h in day 3 morning during IVF-ET process.
methodsEmbryos were retrospectively assessed during 08:00-09:00 on the morning of day 3 in the control group, and were assessed once again at 16:00 in the afternoon in the extended culture (EC) group. The embryos with good developmental potential were preferentially selected to transfer. The cumulative pregnancy outcomes were analyzed in one oocyte retrieval cycle.
resultsSimilar proportions were found in the rates of cumulative clinical pregnancy, cumulative live birth, and the perinatal/neonatal outcomes per oocyte retrieval cycle (P > 0.05). But higher total clinical pregnancy rate, higher total implantation rate, and lower total abortion rate were obtained in the EC group (P < 0.05). After EC, 53.58% of the embryos were able to continue to develop. The transferred embryos were mainly composed of ≥ 8-cell embryos (75.90%) in the EC group and ≤ 8-cell embryos (82.92%) in the control group. Interestingly, the implantation rates were increasingly improved with the increasing blastomere number up to 56.31% at the morula stage in the EC group, while they were limited to 32.33% at 8-cell stage in the control group.
conclusionsThe extended culture of day 3 embryos for 7-8 h not only reduced the risk of IVF-ET treatment compared to blastocyst culture through another 2-3 days, but also improved the clinical outcomes and the efficiency of every transferred cycle and every transferred embryo.
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