Evidence map›Paper›PMID 29124329›Full record

Trial reportInternational journal of colorectal disease2018

Recruitment to and pilot results of the PACES randomized trial of physical exercise during adjuvant chemotherapy for colon cancer.

Hanna van Waart, Martijn M Stuiver, Wim H van Harten, Edwin Geleijn, Marianne de Maaker-Berkhof, Jolanda Schrama, Maud M Geenen, Jetske M Meerum Terwogt, Simone M van den Heiligenberg, Jeannette A J H Hellendoorn-van Vreeswijk and 2 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of colorectal disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 13 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 13 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Effectiveness of exercise interventions in patients with colorectal cancer during adjuvant chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  7. Efficacy of resistance training during adjuvant chemotherapy and radiation therapy in cancer care: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Hanna van WaartDivision of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Martijn M StuiverDepartment of Physical Therapy, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Wim H van HartenDivision of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.
Edwin GeleijnDepartment of Rehabilitation, VU University Medical Center, Amsterdam, The Netherlands.
Marianne de Maaker-BerkhofDepartment of Public and Occupational Health, VU University Medical Center, Amsterdam, The Netherlands.
Jolanda SchramaDepartment of Internal Medicine, Spaarne Gasthuis, Hoofddorp, The Netherlands.
Maud M GeenenDepartment of Internal Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
Jetske M Meerum TerwogtDepartment of Internal Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
Simone M van den HeiligenbergEsperanz, Medical Oncology, North Holland, The Netherlands.
Jeannette A J H Hellendoorn-van VreeswijkComprehensive Cancer Centre the Netherlands, Amsterdam, The Netherlands.
Gabe S SonkeDepartment of Medical Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Neil K AaronsonDivision of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. n.aaronson@nki.nl.
The Netherlands Cancer Institute · NLAmsterdam UMC Location VUmc · NLOLVG · NLBasko Healthcare · NLNetherlands Comprehensive Cancer Organisation · NLSpaarne Gasthuis · NL

Funding

KWF Kankerbestrijding ALPE 2009- 4299
6 · The paper itself

Abstract

purposeWe report the recruitment rate, reasons for and factors influencing non-participation, and descriptive results of a randomized controlled trial of two different exercise programs for patients with colon cancer undergoing adjuvant chemotherapy.

methodsParticipants were randomized to a low-intensity, home-based program (Onco-Move), a moderate- to high-intensity, combined supervised resistance and aerobic exercise program (OnTrack), or Usual Care. Non-participants provided reasons for non-participation and were asked to complete a questionnaire assessing behavioral and attitudinal variables. Trial participants completed performance-based and self-reported outcome measures prior to randomization, at the end of chemotherapy, and at the 6-month follow-up.

resultsTwenty-three of 63 referred patients agreed to participate in the trial. All 40 non-participants provided reasons for non-participation. Forty-five percent of the non-participants completed the questionnaire. Those who did not want to exercise had higher fatigue scores at baseline and a more negative attitude toward exercise. Compliance to both programs was high and no adverse events occurred. On average, the colon cancer participants were able to maintain or improve their physical fitness levels and maintain or decrease their fatigue levels during chemotherapy and follow-up.

conclusionsRecruitment of patients with colon cancer to a physical exercise trial during adjuvant chemotherapy proved to be difficult, underscoring the need to develop more effective strategies to increase participation rates. Both home-based and supervised programs are safe and feasible in patients with colon cancer undergoing chemotherapy. Effectiveness needs to be established in a larger trial.

trial registrationNetherlands Trial Register - NTR2159.

Indexed as

ExerciseChemotherapy, AdjuvantColonic NeoplasmsDemographyFatigueFemaleFollow-Up StudiesHumansMaleMiddle AgedMuscle StrengthPatient CompliancePhysical FitnessPilot ProjectsQuality of LifeSelf ReportCancerChemotherapyExerciseParticipationPhysical activity

Identifiers

PMID29124329
OpenAlexW2768050665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.