ArticleBiochemistry and biophysics reports2015
Antimicrobial activity of the toxin VdTX-I from the spider
Article in Biochemistry and biophysics reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Focusing on the Unfocused: Prominence of Proteo-transcriptomic Studies on Venomous Sea Snakes.Biochemical genetics · 2026Review
- Nature's Arsenal: Uncovering Antibacterial Agents Against Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2025Review
- Antimicrobial activity and partial chemical structure of acylpolyamines isolated from the venom of the spiderThe journal of venomous animals and toxins including tropical diseases · 2022Article
- Brazilian Theraphosidae: a toxicological point of view.The journal of venomous animals and toxins including tropical diseases · 2021Review
- Antimicrobials from Venomous Animals: An Overview.Molecules (Basel, Switzerland) · 2020Review
- Two Tachykinin-Related Peptides with Antimicrobial Activity Isolated fromMicrobiology insights · 2020Article
- Anticancer, antimicrobial, and analgesic activities of spider venoms.Toxicology research · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently there is an urgent need to develop new classes of antimicrobial agents with different mechanisms of action from conventionally antibiotics used for the control of pathogenic microorganisms. The acylpolyamine called VdTX-I was isolated from the venom of the tarantula
methodsAntimicrobial assays were performed in 96 well plates culture against 14 micro-organisms (fungi, yeasts and bacteria), which were tested concentrations from 0.19 to 100 μM of VdTX-I. After qualitative analysis, dose-response curve assays were performed in bacterial kill curve using MTT reagent and hemolytic assay.
resultsThe antimicrobial activity of the VdTX-I toxin was observed in 12 tested species of
conclusionsThe VdTX-I toxin has a significant antimicrobial activity, with broad spectrum, and is experimentally inert to mammalian blood cells. GENERAL SIGNIFICANCE: This paper explores the antimicrobial potential of the spider toxin VdTX-I, which can provide a new model to design new antimicrobial drugs.
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Registered trials
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