Photocontrol of the GTPase activity of the small G protein K-Ras by using an azobenzene derivative.

Seigo Iwata, Shinsaku Maruta

Abstract read

In one paragraph

Article in Biochemistry and biophysics reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Seigo IwataDepartment of Bioinformatics, Graduate School of Engineering, Soka University, Hachioji, Tokyo 192-8577, Japan.

Shinsaku MarutaDepartment of Bioinformatics, Graduate School of Engineering, Soka University, Hachioji, Tokyo 192-8577, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The small G protein Ras is a central regulator of cellular signal transduction processes, functioning as a molecular switch. Switch mechanisms utilizing conformational changes in nucleotide-binding motifs have been well studied at the molecular level. Azobenzene is a photochromic molecule that undergoes rapid and reversible isomerization between the

Indexed as

AzobenzeneDMF, N,N-dimethylformamideDTT, dithiothreitolGEF, guanine nucleotide exchange factorGTPaseGTP, guanosine 5ʹ-triphosphateHEPES, 4-(2-hydroxyethyl)-1-piperazineethane-sulfonic acidNBD-GTP, 2ʹ(3ʹ)-O-{6-(N-(7-nitrobenz-2-oxa-l,3-diazol-4-yl)amino)hexanoic}–GTPPAM, 4-phenylazomaleinanilPhotochromic moleculePhotocontrolRasSmall G proteinUV, ultravioletVis, visible

Identifiers

PMID29124213

DOI10.1016/j.bbrep.2015.10.002

PMCPMC5669354

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.