Evidence map›Paper›PMID 29124180›Full record

ArticleBiochemistry and biophysics reports2015

Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change.

Kazuhiro Sakamaki, Naoyuki Iwabe, Hiroaki Iwata, Kenichiro Imai, Chiyo Takagi, Kumiko Chiba, Chisa Shukunami, Kentaro Tomii, Naoto Ueno

Open access · goldAbstract read
In one paragraph

Article in Biochemistry and biophysics reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. FLIP(L): the pseudo-caspase.The FEBS journal · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kazuhiro SakamakiDepartment of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan.
Naoyuki IwabeDepartment of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
Hiroaki IwataMulti-scale Research Center for Medical Science, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.
Kenichiro ImaiBiotechnology Research Institute for Drug Discovery, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan.
Chiyo TakagiDepartment of Developmental Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan.
Kumiko ChibaDepartment of Animal Development and Physiology, Graduate School of Biostudies, Kyoto University, Kyoto 606-8501, Japan.
Chisa ShukunamiDepartment of Cellular Differentiation, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.
Kentaro TomiiBiotechnology Research Institute for Drug Discovery, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo 135-0064, Japan.
Naoto UenoDepartment of Developmental Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan.
Kyoto University · JPNational Institute for Basic Biology · JPNational Institute of Advanced Industrial Science and Technology · JPKyushu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular FLICE-like inhibitory protein (c-FLIP, gene symbol

Indexed as

ApoptosisCARD, caspase-recruitment domainCASc, Caspase, interleukin-1 β converting enzyme homologsCaspase-8c-FLIP, cellular FLICE-like inhibitory proteinCHX, cycloheximideDED, death effector domainEGFP, enhanced green fluorescent proteinEmbryogenesisEvolutionFADD, Fas-associated death domain proteinMO, morpholino oligonucleotideNF-κBNF-κB, Nuclear factor-kappa BODC, ornithine decarboxylasePCR, polymerase chain reactionPseudocatalytic triadRT-PCR, reverse transcription-polymerase chain reactionTRAF2, tumor necrosis factor receptor-associated factor 2tubα6, tubulin α6

Identifiers

PMID29124180
PMCPMC5668880
OpenAlexW2163530926

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.