Evidence map›Paper›PMID 29124176›Full record

ArticleBiochemistry and biophysics reports2015

The polyglutamine-expanded androgen receptor has increased DNA binding and reduced transcriptional activity.

Sergey Belikov, Laura C Bott, Kenneth H Fischbeck, Örjan Wrange

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry and biophysics reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Polyglutamine expansion induced dynamic misfolding of androgen receptor.Protein science : a publication of the Protein Society · 2025
    Article
  4. Article
  5. Review
  6. Molecular Mechanisms and Therapeutics for SBMA/Kennedy's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019
    Review
  7. Polyglutamine Repeats in Viruses.Molecular neurobiology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Sergey BelikovDepartment of Cell and Molecular Biology, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Laura C BottDepartment of Cell and Molecular Biology, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Kenneth H FischbeckNeurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Örjan WrangeDepartment of Cell and Molecular Biology, Karolinska Institutet, SE-17177 Stockholm, Sweden.
Karolinska Institutet · SENational Institute of Neurological Disorders and Stroke · USNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Expansion of a polyglutamine-encoding trinucleotide CAG repeat in the androgen receptor (AR) to more than 37 repeats is responsible for the X-linked neuromuscular disease spinal and bulbar muscular atrophy (SBMA). Here we evaluated the effect of polyglutamine length on AR function in

Indexed as

Androgen receptorAR, androgen receptorARE(s), androgen response element(s)bp, basepairChromatinDMS, dimethylsulphateDNA bindingExpanded polyglutamine repeatMMTV, mouse mammary tumor virusNTD, N-terminal domainpolyQ, polyglutamineSBMA, spinal and bulbar muscular atrophyTranscriptionWB, Western blottingXenopus oocyte

Identifiers

PMID29124176
PMCPMC5668691
OpenAlexW1038051558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.