Evidence map›Paper›PMID 29124153›Full record

ArticleBiochemistry and biophysics reports2015

Human retinal pigment epithelial cell proliferation by the combined stimulation of hydroquinone and advanced glycation end-products via up-regulation of

Hiroki Tsujinaka, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Hiroyo Ota, Maiko Takeda, Takanori Fujimura, Shin Takasawa, Nahoko Ogata

Open access · goldAbstract read
In one paragraph

Article in Biochemistry and biophysics reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Role of the JAK/STAT pathway in a streptozotocin-induced diabetic retinopathy mouse model.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Article
  4. Upregulation ofInternational journal of molecular sciences · 2022
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Intermittent Hypoxia Upregulates theInternational journal of molecular sciences · 2021
    Article
  10. Article
  11. Resvega Alleviates Hydroquinone-Induced Oxidative Stress in ARPE-19 Cells.International journal of molecular sciences · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Intermittent Hypoxia Up-RegulatesInternational journal of molecular sciences · 2019
    Article
  16. Intermittent Hypoxia Up-Regulates Gene Expressions ofInternational journal of molecular sciences · 2019
    Article
  17. Article
  18. Article
  19. Expression ofBiochemistry and biophysics reports · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Hiroki TsujinakaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8521 Nara, Japan.
Asako Itaya-HironakaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8521 Nara, Japan.
Akiyo YamauchiDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8521 Nara, Japan.
Sumiyo Sakuramoto-TsuchidaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8521 Nara, Japan.
Hiroyo OtaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8521 Nara, Japan.
Maiko TakedaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8521 Nara, Japan.
Takanori FujimuraDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8521 Nara, Japan.
Shin TakasawaDepartment of Biochemistry, Nara Medical University, 840 Shijo-cho, Kashihara, 634-8521 Nara, Japan.
Nahoko OgataDepartment of Ophthalmology, Nara Medical University, Kashihara, 634-8522 Nara, Japan.
Nara Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although recent research showed that advanced glycation endproduct (AGE) and hydroquinone (HQ) are related to the pathogenesis of age-related macular degeneration (AMD), the mechanism how AGE and HQ induce or accelerate AMD remains elusive. In the present study, we examined the effects of AGE and HQ on changes of human retinal pigment epithelial (RPE) cell numbers and found that the viable cell numbers were markedly reduced by HQ by apoptosis and that AGE prevented the decreases of HQ-treated cell numbers by increased replicative DNA synthesis of RPE cells without changing apoptosis. Real-time RT-PCR revealed that

Indexed as

Advanced glycation endproduct(s)AGE, advanced glycation endproductAge-related macular degenerationAMD, age-related macular degenerationBSA, bovine serum albuminELISA, enzyme-linked immunosorbent assayFCS, fetal calf serumHQ, hydroquinoneHydroquinoneIdU, 5ʹ-Indo-2ʹ-deoxyuridineRAGE, receptor for advanced glycation endproductRetinal pigment epithelial cellsRPE, retinal pigment epithelialRT-PCR, reverse transcription polymerase chain reaction;siRNA, small interfering RNASP1, specificity protein 1SR, scavenger receptorTUNEL, terminal deoxynucleotidyl transferase dUTP nick end labelingVascular endothelial growth factorVEGF, vascular endothelial growth factorWST-8, 2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium monosodium salt

Identifiers

PMID29124153
PMCPMC5668646
OpenAlexW780982360

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.