HaCaT anchorage blockade leads to oxidative stress, DNA damage and DNA methylation changes.

Rodrigo A da Silva, Flavia Sammartino Mariano, Aline C Planello, Sergio R P Line, Ana Paula de Souza

Open access · goldAbstract read

In one paragraph

Article in Biochemistry and biophysics reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.3field-weighted citation impact, top 40% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

Protective effects ofToxicology reports · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Rodrigo A da SilvaDepartment of Morphology, School of Dentistry of Piracicaba, University of Campinas - UNICAMP, Av. Limeira, 901, 13414-018 Piracicaba, SP, Brazil.

Flavia Sammartino MarianoDepartment of Morphology, School of Dentistry of Piracicaba, University of Campinas - UNICAMP, Av. Limeira, 901, 13414-018 Piracicaba, SP, Brazil.

Aline C PlanelloDepartment of Morphology, School of Dentistry of Piracicaba, University of Campinas - UNICAMP, Av. Limeira, 901, 13414-018 Piracicaba, SP, Brazil.

Sergio R P LineDepartment of Morphology, School of Dentistry of Piracicaba, University of Campinas - UNICAMP, Av. Limeira, 901, 13414-018 Piracicaba, SP, Brazil.

Ana Paula de SouzaDepartment of Morphology, School of Dentistry of Piracicaba, University of Campinas - UNICAMP, Av. Limeira, 901, 13414-018 Piracicaba, SP, Brazil.

Universidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell adhesion plays an important role in neoplastic transformation. Thus, anchorage-independent growth and epithelial-mesenchymal transition, which are features associated to anoikis-resistance, are vital steps in cancer progression and metastatic colonization. Cell attachment loss may induce intracellular oxidative stress, which triggers DNA damage as methylation changes. HaCaT lineage cells were submitted to periods of 1, 3, 5 and 24 h of anchorage blockage with the purpose of study of oxidative stress effect on changes in the DNA methylation pattern, derived from attachment blockade. Through this study, HaCaT anchorage blockage-induced oxidative stress was reported to mediate alterations in global DNA methylation changes and into

Indexed as

Anchorage blockadeAnoikis-resistanceDNA methylationEpigeneticsOxidative stressReactive oxygen species

Identifiers

PMID29124149

DOI10.1016/j.bbrep.2015.05.008

PMCPMC5668640

OpenAlexW561613982

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.