ArticleBiochemistry and biophysics reports2015
Model of ribosomal translocation coupled with intra- and inter-subunit rotations.
Article in Biochemistry and biophysics reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Mechanisms of Hypomagnetic Field Biological Effects: Quantum Rotator Versus Radical Pair.International journal of molecular sciences · 2026Article
- Molecular Stiffening by Macrocycle Clustering.Angewandte Chemie (International ed. in English) · 2025Article
- A model for ribosome translocation based on the alternated displacement of its subunits.European biophysics journal : EBJ · 2023Article
- Rotations of macromolecules affect nonspecific biological responses to magnetic fields.Scientific reports · 2018Article
- Mechanism of ribosome translation through mRNA secondary structures.International journal of biological sciences · 2017Review
- Dynamic relationships between ribosomal conformational and RNA positional changes during ribosomal translocation.Heliyon · 2016Article
- Model of the pathway of -1 frameshifting: Kinetics.Biochemistry and biophysics reports · 2016Article
- Model of the pathway of -1 frameshifting: Long pausing.Biochemistry and biophysics reports · 2016Article
- Dwell-Time Distribution, Long Pausing and Arrest of Single-Ribosome Translation through the mRNA Duplex.International journal of molecular sciences · 2015Article
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1 author.
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Abstract
The ribosomal translocation involves both intersubunit rotations between the small 30S and large 50S subunits and the intrasubunit rotations of the 30S head relative to the 30S body. However, the detailed molecular mechanism on how the intersubunit and intrasubunit rotations are related to the translocation remains unclear. Here, based on available structural data a model is proposed for the ribosomal translocation, into which both the intersubunit and intrasubunit rotations are incorporated. With the model, we provide quantitative explanations of in vitro experimental data showing the biphasic character in the fluorescence change associated with the mRNA translocation and the character of a rapid increase that is followed by a slow single-exponential decrease in the fluorescence change associated with the 30S head rotation. The calculated translation rate is also consistent with the in vitro single-molecule experimental data.
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