Evidence map›Paper›PMID 29124007›Full record

ArticleRespiratory medicine case reports2017

Immunotherapy "Shock" with vitiligo due to nivolumab administration as third line therapy in lung adenocarcinoma.

Paul Zarogoulidis, Haidong Huang, Theodora Tsiouda, Chrysa Sardeli, Georgia Trakada, Lemonia Veletza, Anastasios Kallianos, Christoforos Kosmidis, Aggeliki Rapti, Liana Papaemmanouil and 4 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Respiratory medicine case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Lung cancer, treatment and nutritional status.Molecular and clinical oncology · 2021
    Article
  4. Article
  5. Immune checkpoint inhibitor-related dermatologic adverse events.Journal of the American Academy of Dermatology · 2020
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Cutaneous toxicities of antineoplastic agents: data from a large cohort of Greek patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Article
  12. Melanoma and Vitiligo: In Good Company.International journal of molecular sciences · 2019
    Review
  13. Treatment Outcomes of Immune-Related Cutaneous Adverse Events.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019
    Article
  14. Article
  15. Inhaled Cisplatin for NSCLC: Facts and Results.International journal of molecular sciences · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Paul ZarogoulidisPulmonary-Oncology Department, "Theageneio" Anticancer Hospital, Thessaloniki, Greece.
Haidong HuangDepartment of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
Theodora TsioudaPulmonary-Oncology Department, "Theageneio" Anticancer Hospital, Thessaloniki, Greece.
Chrysa SardeliDepartment of Pharmacology & Clinical Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Georgia TrakadaDivision of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, Greece.
Lemonia VeletzaDivision of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, Greece.
Anastasios KallianosDivision of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, Athens, Greece.
Christoforos KosmidisSurgery Department, "Interbalkan" European Medical Center, Thessaloniki, Greece.
Aggeliki RaptiSecond Pulmonary Clinic, "Sotiria" Chest Diseases Hospital, Athens, Greece.
Liana PapaemmanouilPathology Department, "G. Papanikolaou" General Hospital, Thessaloniki, Greece.
Dimitrios HatzibougiasPrivate Pathology Center "Microdiagnostics", Thessaloniki, Greece.
Dimitrios DrougasPrivate Scientigraphy Department, "Bioiatriki", Thessaloniki, Greece.
Chong BaiDepartment of Respiratory and Critical Care Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China.
Wolfgang Hohenforst-SchmidtSana Clinic Group Franken, Department of Cardiology/Pulmonology/Intensive Care/Nephrology, "Hof'' Clinics, University of Erlangen, Hof, Germany.
National and Kapodistrian University of Athens · GRSecond Military Medical University · CNTheageneio General Hospital · GRAristotle University of Thessaloniki · GRG. Papanikolaou General Hospital · GRInterbalkan Medical Center · GRSana Klinikum · DESotiria General Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small cell lung cancer is still diagnosed at late stage due to the lack of early symptoms and methods of diagnostic prevention. In the past ten years several targeted therapies have been introduced or explored. Tyrosine kinase inhibitors and immunotherapy are currently considered the most effective and safe therapies in comparison to the non-specific cytotoxic agents. Regarding tyrosine kinase inhibitors the adverse effects have been fully explored, however; on the other hand for immunotherapy there are still several issues to be clarified. We report a rare case of a patient with lung cancer adenocarcinoma who developed vitiligo throughout his body after nivolumab administration.

Indexed as

AdenocarcinomaEBUSNivolumabNSCLC

Identifiers

PMID29124007
PMCPMC5671388
OpenAlexW2767156652

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.