ArticleNeural plasticity2017
Spinal Excitability Changes after Transspinal and Transcortical Paired Associative Stimulation in Humans.
Article in Neural plasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04624607 (Transspinal-Transcortical Paired Stimulation for Neuroplasticity and Recovery After SCI), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transspinal-Transcortical Paired Stimulation for Neuroplasticity and Recovery After SCI
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Modulations in neural pathways excitability post transcutaneous spinal cord stimulation among individuals with spinal cord injury: a systematic review.Frontiers in neuroscience · 2024Pooled it
- Optimizing transcutaneous spinal stimulation: excitability of evoked spinal reflexes is dependent on electrode montage.Journal of neuroengineering and rehabilitation · 2025Trial
- Brain and spinal cord paired stimulation coupled with locomotor training affects polysynaptic flexion reflex circuits in human spinal cord injury.Experimental brain research · 2022Trial
- Cervicothoracic trans-spinal magnetic stimulation: effect of coil position and orientation on spinal motor evoked potentials.Experimental brain research · 2026Article
- Study design considerations in clinical trials testing transcutaneous stimulation for spinal cord injury.Spinal cord · 2026Review
- Use of transcutaneous spinal cord stimulation to explore inhibitory and facilitatory circuits in muscles of the human lower limb.Experimental physiology · 2026Article
- Timing-dependent synergies between noninvasive motor cortex and spinal cord stimulation in chronic cervical spinal cord injury.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Optimal sigmoid function models for analysis of transspinal evoked potential recruitment curves recorded from different muscles.PloS one · 2025Article
- Optimizing Transcutaneous Spinal Stimulation: Excitability of Evoked Spinal Reflexes is Dependent on Electrode Montage.Research square · 2024Article
- What Else Can Be Done by the Spinal Cord? A Review on the Effectiveness of Transpinal Direct Current Stimulation (tsDCS) in Stroke Recovery.International journal of molecular sciences · 2023Review
- Physiological effects of cathodal electrode configuration for transspinal stimulation in humans.Journal of neurophysiology · 2022Article
- Brain and spinal cord paired stimulation coupled with locomotor training facilitates motor output in human spinal cord injury.Frontiers in neurology · 2022Article
- A New Paired Associative Stimulation Protocol with High-Frequency Peripheral Component and High-Intensity 20 Hz Repetitive Transcranial Magnetic Stimulation-A Pilot Study.International journal of environmental research and public health · 2021Article
- Temporal Profile of Descending Cortical Modulation of Spinal Excitability: Group and Individual-Specific Effects.Frontiers in integrative neuroscience · 2021Article
- Neuronal Actions of Transspinal Stimulation on Locomotor Networks and Reflex Excitability During Walking in Humans With and Without Spinal Cord Injury.Frontiers in human neuroscience · 2021Article
- Neurophysiological Changes After Paired Brain and Spinal Cord Stimulation Coupled With Locomotor Training in Human Spinal Cord Injury.Frontiers in neurology · 2021Article
- Motor Point Stimulation in Spinal Paired Associative Stimulation can Facilitate Spinal Cord Excitability.Frontiers in human neuroscience · 2020Article
- Cortical and Subcortical Contributions to Neuroplasticity after Repetitive Transspinal Stimulation in Humans.Neural plasticity · 2019Article
- Transspinal stimulation increases motoneuron output of multiple segments in human spinal cord injury.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paired associative stimulation (PAS) produces enduring neuroplasticity based on Hebbian associative plasticity. This study established the changes in spinal motoneuronal excitability by pairing transcortical and transspinal stimulation. Transcortical stimulation was delivered after (transspinal-transcortical PAS) or before (transcortical-transspinal PAS) transspinal stimulation. Before and after 40 minutes of each PAS protocol, spinal neural excitability was assessed based on the amplitude of the transspinal-evoked potentials (TEPs) recorded from ankle muscles of both legs at different stimulation intensities (recruitment input-output curve). Changes in TEPs amplitude in response to low-frequency stimulation and paired transspinal stimuli were also established before and after each PAS protocol. TEP recruitment input-output curves revealed a generalized depression of TEPs in most ankle muscles of both legs after both PAS protocols that coincided with an increased gain only after transcortical-transspinal PAS. Transcortical-transspinal PAS increased and transspinal-transcortical PAS decreased the low-frequency-dependent TEP depression, whereas neither PAS protocol affected the TEP depression observed upon paired transspinal stimuli. These findings support the notion that transspinal and transcortical PAS has the ability to alter concomitantly cortical and spinal synaptic activity. Transspinal and transcortical PAS may contribute to the development of rehabilitation strategies in people with bilateral increased motoneuronal excitability due to cortical or spinal lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.