ArticleBritish journal of pain2017
Chronic post-amputation pain: peri-operative management - Review.
Article in British journal of pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 44 citations in OpenAlex.
- From Amputation to Persistent Pain: A Review of Molecular and Cellular Processes in Phantom Limb Pain.International journal of molecular sciences · 2026Review
- Intrathecal Ziconotide Long-Term Management in Chronic Postamputation Pain.Case reports in anesthesiology · 2026Article
- Opioid consumption after lower limb amputation in Medicare beneficiaries.PM & R : the journal of injury, function, and rehabilitation · 2025Article
- Review
- Genome-Wide Expression Profiling by RNA-Sequencing in Spinal Cord Dorsal Horn of a Rat Chronic Postsurgical Pain Model to Explore Potential Mechanisms Involved in Chronic Pain.Journal of pain research · 2022Article
- Management of Phantom Limb Pain through Thalamotomy of the Centro-Median Nucleus.Neurology international · 2021Article
- Chinese Association for the Study of Pain: Expert consensus on chronic postsurgical pain.World journal of clinical cases · 2021Review
- Peripheral Nerve Blockade with Combined Standard and Liposomal Bupivacaine in Major Lower-Extremity Amputation.Pain practice : the official journal of World Institute of Pain · 2021Observational
- Predicting the Transition to Chronic Pain 6 Months After an Emergency Department Visit for Acute Pain: A Prospective Cohort Study.The Journal of emergency medicine · 2020Observational
- Role of Potassium Ions Quantum Tunneling in the Pathophysiology of Phantom Limb Pain.Brain sciences · 2020Article
- Phantom limb pain: A literature review.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2018Review
- Major lower limb amputation audit - introduction and implementation of a multimodal perioperative pain management guideline.British journal of pain · 2018Article
- Major lower limb amputation audit - introduction and implementation of a multimodal perioperative pain management guideline.British journal of pain · 2018Article
- Peri-operative management and analgesic strategy for a patient undergoing quadruple limb amputation.Anaesthesia reportsArticle
- Multi-site nerve block catheters for postoperative analgesia in extended scapulectomy and free-flap reconstruction.Anaesthesia reportsArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designNarrative review.
methodEight bibliographic databases were searched for studies published in the (last five years up until Feb 2017). For the two database searches (Cochrane and DARE), the time frame was unlimited. The review involved keyword searches of the term 'Amputation' AND 'chronic pain'. Studies selected were interrogated for any association between peri-operative factors and the occurrence of chronic post amputation pain (CPAP).
resultsHeterogeneity of study populations and outcome measures prevented a systematic review and hence a narrative synthesis of results was undertaken. The presence of variation in two gene alleles (GCH1 and KCNS1) may be relevant for development of CPAP. There was little evidence to draw conclusions on the association between age, gender and CPAP. Pre-operative anxiety and depression influenced pain intensity post operatively and long-term post amputation pain (CPAP). The presence of pre-amputation pain is correlated to the development of acute and chronic post amputation pain while evidence for the association of post-operative pain with CPAP is modest. Regional anaesthesia and peri-neural catheters improve acute postoperative pain relief but evidence on their efficacy to prevent CPAP is limited. A suggested whole system pathway based on current evidence to optimize peri-operative amputation pain is described.
conclusionThe current evidence suggests that optimized peri-operative analgesia reduces the incidence of acute peri-operative pain but no firm conclusion can be drawn on reducing risk for CPAP.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.