Evidence map›Paper›PMID 29123502›Full record

ArticleFrontiers in endocrinology2017

Anaplastic Thyroid Cancer in Sicily: The Role of Environmental Characteristics.

Martina Tavarelli, Pasqualino Malandrino, Paolo Vigneri, Pierina Richiusa, Adele Maniglia, Maria A Violi, Giulia Sapuppo, Veronica Vella, Gabriella Dardanoni, Riccardo Vigneri and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Cancer Incidence in Volcanic Areas: A Systematic Review.Asian Pacific journal of cancer prevention : APJCP · 2022
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Martina TavarelliEndocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy.
Pasqualino MalandrinoEndocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy.
Paolo VigneriMedical Oncology, Department of Clinical Experimental Medicine, University of Catania, Policlinic Hospital, Catania, Italy.
Pierina RichiusaEndocrinology, Di.Bi.M.I.S., University of Palermo, Palermo, Italy.
Adele ManigliaEndocrinology, Di.Bi.M.I.S., University of Palermo, Palermo, Italy.
Maria A VioliDepartment of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Giulia SapuppoEndocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy.
Veronica VellaMotor Sciences, School of Human and Social Sciences, "Kore" University, Enna, Italy.
Gabriella DardanoniOsservatorio Epidemiologico Regionale, Assessorato Salute Regione Siciliana, Palermo, Italy.
Riccardo VigneriEndocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy.
Gabriella PellegritiEndocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy.
Ospedale Garibaldi · ITUniversity of Catania · ITUniversity of Palermo · ITInstitute of Biostructure and Bioimaging · ITRegione Siciliana · ITUniversità degli Studi di Enna Kore · ITUniversity of Messina · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnaplastic thyroid cancer (ATC) is a rare but extremely aggressive cancer of the thyroid, contributing up to 30-40% of thyroid cancer-specific mortality. We analyzed ATC characteristics and survival rates in Sicily to evaluate the possible influence of environmental factors. With this aim, data regarding ATC incidences in urban/rural and industrial, iodine-deficient, and volcanic vs control areas were compared in Sicily as well as ATC data from Sicily and USA.

methodsUsing the Sicilian Register of Thyroid Cancer (SRTC) database incidence, age, gender, tumor size and histotype, extrathyroidal extension, stage, and coexistence with pre-existing differentiated thyroid cancer (DTC) were evaluated in different areas of Sicily and also compared with Surveillance Epidemiology and End Results data in USA.

resultsForty-three ATCs were identified in Sicily in the period 2002-2009. In our series only age <70 years at diagnosis (

conclusionThe similar ATC data observed in Sicily and USA (having different genetic background and lifestyle) and the increased ATC incidence in the volcanic area of Sicily paralleling the increased incidence of papillary thyroid cancer are compatible with the possibility that casual additional mutations, more frequent in a background of increased cell replication like DCT, are the major causes of ATC rather than genetic background and/or direct environmental influences.

Indexed as

anaplastic thyroid cancerthyroid cancerthyroid cancer and volcanic environmentthyroid cancer epidemiologyThyroid Cancer Registry

Identifiers

PMID29123502
PMCPMC5662896
OpenAlexW2766476105

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.