ArticleJournal of blood medicine2017
The prevalence of abnormal leukocyte count, and its predisposing factors, in patients with sickle cell disease in Saudi Arabia.
Article in Journal of blood medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Complete Blood Count Profile in Steady State Sickle Cell Disease Patient: A Systematic Review and Meta-Analysis.Health science reports · 2026Article
- Laboratory indices of hospitalized sickle cell disease patients, prevalence and antimicrobial susceptibility of pathogenic bacterial isolates at MRCG ward in the Gambia.BMC infectious diseases · 2023Article
- Impact of Abnormal Leukocyte Count in the Pathophysiology of Sickle Cell Anemia.Journal of blood medicine · 2022Article
- A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemic.Orphanet journal of rare diseases · 2021Review
- Paediatric sickle cell disease at a tertiary hospital in Malawi: a retrospective cross-sectional study.BMJ paediatrics open · 2021Article
- Patterns and patient factors associated with loss to follow-up in the Muhimbili sickle cell cohort, Tanzania.BMC health services research · 2020Article
- Detection of BCL11A and HBS1L-MYB Genotypes in Sickle Cell Anemia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2020Article
- Successful liver transplantation for acute sickle cell intrahepatic cholestasis: A case report and review of the literature.World journal of hepatology · 2020Article
- Leucocytosis and Asymptomatic Urinary Tract Infections in Sickle Cell Patients at a Tertiary Hospital in Zambia.Anemia · 2020Article
- Biochemical and Molecular analysis of the beta-globin gene on Saudi sickle cell anemia.Saudi journal of biological sciences · 2019Article
- Neutrophils remain detrimentally active in hydroxyurea-treated patients with sickle cell disease.PloS one · 2019Article
- Hematological parameters in Ghanaian sickle cell disease patients.Journal of blood medicine · 2018Article
- Vitamin D deficiency in pediatric sickle cell disease patients without crisis - A cry to investigate it on priority.International journal of health sciencesArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHigh white blood cell (WBC) count is an indicator of sickle cell disease (SCD) severity, however, there are limited studies on WBC counts in Saudi Arabian patients with SCD. The aim of this study was to estimate the prevalence of abnormal leukocyte count (either low or high) and identify factors associated with high WBC counts in a sample of Saudi patients with SCD.
methodsA cross-sectional and retrospective chart review study was carried out on 290 SCD patients who were routinely treated at King Fahad Hospital in Hofuf, Saudi Arabia. An interview was conducted to assess clinical presentations, and we reviewed patient charts to collect data on blood test parameters for the previous 6 months.
resultsAlmost half (131 [45.2%]) of the sample had abnormal leukocyte counts: low WBC counts 15 (5.2%) and high 116 (40%). High WBC counts were associated with shortness of breath (
conclusionAbnormal leukocyte count was common: approximately five in ten Saudi SCD patients assessed in this sample. Male gender, cough, low hemoglobin, and low heart rate were associated with high WBC count. Strategies targeting high WBC count could prevent disease complication and thus could be beneficial for SCD patients.
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