Evidence map›Paper›PMID 29123433›Full record

ArticleLung Cancer (Auckland, N.Z.)2017

Real-world practice patterns for patients with advanced non-small cell lung cancer: multicenter retrospective cohort study in Japan.

Hiroshi Isobe, Kiyoshi Mori, Koichi Minato, Hideki Katsura, Kazuko Taniguchi, Ashwini Arunachalam, Smita Kothari, Xiting Cao, Terufumi Kato

Open access · goldAbstract read
In one paragraph

Article in Lung Cancer (Auckland, N.Z.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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  8. Testing forOncoTargets and therapy · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Hiroshi IsobeDepartment of Medical Oncology, KKR Sapporo Medical Center, Hokkaido.
Kiyoshi MoriDepartment of Thoracic Diseases, Division of Thoracic Oncology, Tsuboi Cancer Center Hospital, Fukushima.
Koichi MinatoDepartment of Respiratory Medicine, Gunma Prefectural Cancer Center, Gunma.
Hideki KatsuraDivision of Respiratory Medicine, Tokyo Women's Medical University Yachiyo Medical Center, Chiba.
Kazuko TaniguchiMarket Access, MSD K.K., Tokyo, Japan.
Ashwini ArunachalamCenter for Observational & Real World Evidence (CORE), Merck & Co., Inc., Kenilworth, NJ, USA.
Smita KothariCenter for Observational & Real World Evidence (CORE), Merck & Co., Inc., Kenilworth, NJ, USA.
Xiting CaoCenter for Observational & Real World Evidence (CORE), Merck & Co., Inc., Kenilworth, NJ, USA.
Terufumi KatoDepartment of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Kanagawa, Japan.
Merck & Co., Inc., Rahway, NJ, USA (United States) · USFukushima Medical University Hospital · JPGunma Prefectural Cardiovascular Center · JPKanagawa Cardiovascular and Respiratory Center · JPMSD K.K. (Japan) · JPNTT Medical Center · JPTokyo Women's Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecommended therapies for advanced/metastatic non-small cell lung cancer (NSCLC) have changed with the advent of targeted therapies. The objectives of this retrospective chart review study were to describe treatment patterns, biomarker testing practices, and health care resource use for advanced NSCLC at 5 sites in Japan. PATIENTS AND

methodsWe studied anonymized medical record data of patients aged ≥18 years who initiated systemic therapy for newly diagnosed stage IIIB or IV NSCLC from January 2011 through June 2013. Data were analyzed descriptively by histology and mutation status. Overall survival was estimated using the Kaplan-Meier method.

resultsWe studied 175 patients, including 43 (25%), 129 (74%), and 3 (2%) with squamous, nonsquamous, and unknown NSCLC histology, respectively; 83% had stage IV NSCLC. Overall, 123 patients (70%) were male; the median age was 70 years (range, 47-86); and 33 (19%) were never-smokers. In the nonsquamous cohort, 105 (81%) and 25 (19%) of patients were tested for epidermal growth factor receptor (

conclusionBiomarker testing is common for nonsquamous NSCLC at the 5 Japanese study sites. Treatment is personalized by mutation status and age, per guideline recommendations.

Indexed as

health care resource useJapannon-small cell lung cancerpredictive biomarkersystemic therapytreatment patterns

Identifiers

PMID29123433
PMCPMC5661576
OpenAlexW2765643220

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.