ArticleInternational journal of women's health2017
Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal.
Article in International journal of women's health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Analysis of low-dose estrogen on callus BMD as measured by pQCT in postmenopausal women.BMC musculoskeletal disorders · 2020Trial
- Gender-Affirming Hormone Treatment Decreases Bone Turnover in Transwomen and Older Transmen.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Trial
- Review
- Metabolic Dysfunction Associated Steatotic Liver Disease and Bone Turnover Markers in Postmenopausal Women: A Cross-Sectional Study in Central Nepal.Health science reports · 2026Article
- Improved bioavailability of raloxifene hydrochloride through nasal administration of poly (methyl vinyl ether-co-maleic acid) nanoparticles in ovariectomized rats.Iranian journal of basic medical sciences · 2026Article
- The correlation between serum alkaline phosphatase and grip strength in middle-aged and elderly people: NHANES 2011-2014.BMC musculoskeletal disorders · 2025Article
- Article
- Nutrition-Based Support for Osteoporosis in Postmenopausal Women: A Review of Recent Evidence.International journal of women's health · 2024Review
- Article
- Article
- FSH may mediate the association between HbA1c and bone turnover markers in postmenopausal women with type 2 diabetes.Journal of bone and mineral metabolism · 2022Article
- Effect of 50-Hertz Sinusoidal Vibration on the Uterus in Ovariectomy-Induced Osteoporotic Rats.Computational and mathematical methods in medicine · 2022Article
- Investigating the Effect of Hydroalcoholic Extract of Licorice Root to Prevent Ovariectomy-Mediated Complications.BioMed research international · 2022Article
- Article
- Effect of Obesity on Plasma Alkaline Phosphatase Activity in Breast Cancer.Reports of biochemistry & molecular biology · 2021Article
- Anatase and Rutile TiOInternational journal of nanomedicine · 2021Article
- Effectiveness of Physical Activity and Finger Millet-Based Food Supplement on Biochemical Parameters and Bone Mineral Density among Premenopausal Women.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis.BMC musculoskeletal disorders · 2020Article
- Effect of estradiol on high glucose‑induced osteoblast injury.Molecular medicine reports · 2019Article
- Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis.Clinical interventions in aging · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoporosis, a common disease worldwide, is characterized by low bone mass and architectural deterioration of bone tissue, leading to enhanced bone fragility and increase in fracture risks. Both menopause and aging are related factors leading to greater risk of bone disease, particularly among postmenopausal women. Hence, the main purpose of this study was to investigate the differences in biochemical markers of bone turnover and to evaluate the association of hormones and age-related factors with biochemical markers between pre- and postmenopausal women.
methodsA descriptive cross-sectional study was conducted over a period of 6 months among the female population of Dholahity community, Lalitpur, Nepal. A total of 496 healthy women were selected based on the questionnaire strategy. Among them, 244 were premenopausal and 252 were postmenopausal women. Different bone markers were evaluated as per the guideline provided by the reagent manufacturer, and hormonal assay, particularly estradiol level assessment, was performed by chemiluminescence immunoassay-based technique.
resultsA significant decrease in serum calcium level and estradiol level was observed in postmenopausal women as compared to premenopausal women, whereas a significant increase in serum phosphorus and alkaline phosphatase (ALP) levels was seen among postmenopausal (
conclusionTimely diagnosis of osteoporosis in women would be of significant benefit for effective care for required populations and help to minimize mortality rate and financial burden of our country.
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