ArticleCancer growth and metastasis2017
Neutrophil-Derived Interleukin 16 in Premetastatic Lungs Promotes Breast Tumor Cell Seeding.
Article in Cancer growth and metastasis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- IL-16 Up-Regulation is Associated with Epithelial Ovarian Cancer Progression and Poor Prognosis in Patients.Clinical medicine & research · 2025Article
- Hyperalgesic Effect Evoked by il-16 and its Participation in Inflammatory Hypernociception in Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024Article
- Identifying drivers of breast cancer metastasis in progressively invasive subpopulations of zebrafish-xenografted MDA-MB-231.Molecular biomedicine · 2022Article
- Article
- Asthma-related inflammation promotes lung metastasis of breast cancer cells through CCL11-CCR3 pathway.Respiratory research · 2021Article
- Triple-Negative Breast Cancer Cells Recruit Neutrophils by Secreting TGF-β and CXCR2 Ligands.Frontiers in immunology · 2021Article
- Improved mouse models and advanced genetic and genomic technologies for the study of neutrophils.Drug discovery today · 2020Review
- Exosomes secreted by prostate cancer cells under hypoxia promote matrix metalloproteinases activity at pre-metastatic niches.Molecular carcinogenesis · 2020Article
- CD62LFrontiers in oncology · 2020Article
- ADAM10 mediates malignant pleural mesothelioma invasiveness.Oncogene · 2019Article
- Article
- Getting TANned: How the tumor microenvironment drives neutrophil recruitment.Journal of leukocyte biology · 2019Review
- TRPM2 modulates neutrophil attraction to murine tumor cells by regulating CXCL2 expression.Cancer immunology, immunotherapy : CII · 2019Article
- Prognostic significance of elevated pretreatment systemic inflammatory markers for patients with prostate cancer: a meta-analysis.Cancer cell international · 2019Article
- Prognostic modeling of the immune-centric transcriptome reveals interleukin signaling candidates contributing to differential patient outcomes.Carcinogenesis · 2018Article
- Integrated analysis of dysregulated long non-coding RNAs/microRNAs/mRNAs in metastasis of lung adenocarcinoma.Journal of translational medicine · 2018Article
- Microenvironment-derived ADAM28 prevents cancer dissemination.Oncotarget · 2018Article
- Significant Association of Interleukin-16 Genetic Variations to Taiwanese Lung Cancer.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The premetastatic niche in distant organs prior to metastatic cell arrival emerged as an important step in the metastatic cascade. However, molecular mechanisms underlying this process are still poorly understood. In particular, whether neutrophil recruitment at a premetastatic stage promotes or inhibits metastatic cell seeding has to be clarified. We aimed at unraveling how neutrophil infiltration in lung parenchyma induced by the distant primary tumor influences the establishment of lung metastasis. Elevated neutrophil counts and IL-16 levels were found in premetastatic lungs in a syngenic mouse model using 4T1 tumor cells. 4T1 cell-derived soluble factors stimulated IL-16 secretion by neutrophils. The functional contribution of IL-16 is supported by metastasis burden reduction in lungs observed on instillation of an IL-16 neutralizing antibody. Moreover, IL-16 promotes
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.