Evidence map›Paper›PMID 29123378›Full record

ArticleDrug design, development and therapy2017

10

Jianxin Zhang, Chen Ming, Wenzhi Zhang, Patrick Nwabueze Okechukwu, Beata Morak-Młodawska, Krystian Pluta, Małgorzata Jeleń, Abdah Md Akim, Kok-Pian Ang, Kah Kooi Ooi

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. The IAP family member BRUCE/BIRC6: an emerging new player in balancing life and death.Apoptosis : an international journal on programmed cell death · 2026
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  6. Ethyl acetate extract ofFrontiers in pharmacology · 2025
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  14. Article
  15. Review
  16. Article
  17. Article
  18. 10Journal of enzyme inhibition and medicinal chemistry · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Jianxin ZhangDepartment of Gynecology and Obstetrics, Capital Medical University Affiliated Beijing Chaoyang Hospital, Beijing.
Chen MingDepartment of Gynecologic Oncology, Taizhou People's Hospital, Jiangsu, People's Republic of China.
Wenzhi ZhangInnoresearch, Subang Jaya.
Patrick Nwabueze OkechukwuDepartment of Biotechnology, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia.
Beata Morak-MłodawskaDepartment of Organic Chemistry, School of Pharmacy with the Division of Laboratory Medicine, The Medical University of Silesia, Sosnowiec, Poland.
Krystian PlutaDepartment of Organic Chemistry, School of Pharmacy with the Division of Laboratory Medicine, The Medical University of Silesia, Sosnowiec, Poland.
Małgorzata JeleńDepartment of Organic Chemistry, School of Pharmacy with the Division of Laboratory Medicine, The Medical University of Silesia, Sosnowiec, Poland.
Abdah Md AkimDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang.
Kok-Pian AngInnoresearch, Subang Jaya.
Kah Kooi OoiDepartment of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang.
Medical University of Silesia · PLCapital Medical University · CNSunway University · MYTaizhou People's Hospital · CNUCSI University · MYUniversiti Putra Malaysia · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The asymptomatic properties and high treatment resistance of ovarian cancer result in poor treatment outcomes and high mortality rates. Although the fundamental chemotherapy provides promising anticancer activities, it is associated with severe side effects. The derivative of phenothiazine, namely, 10

Indexed as

Antineoplastic AgentsApoptosisCaspasesCell Line, TumorCell ProliferationDose-Response Relationship, DrugFemaleG2 Phase Cell Cycle CheckpointsHEK293 CellsHumansInhibitor of Apoptosis ProteinsInhibitory Concentration 50Membrane Potential, MitochondrialM Phase Cell Cycle CheckpointsNeoplasm InvasivenessNF-kappa B10H-3,6-diazaphenothiazineAntineoplastic AgentsBIRC6 protein, humanCaspasesInhibitor of Apoptosis ProteinsNF-kappa BPhenothiazinesReactive Oxygen SpeciesXIAP protein, humanX-Linked Inhibitor of Apoptosis Proteinanticancercancer cell invasionmitochondrial function disruptionovarian canceroxidative damageprogrammed cell death

Identifiers

PMID29123378
PMCPMC5661483
OpenAlexW2766192711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.