ArticleBritish journal of cancer2018
Favourable prognostic role of histological regression in stage III positive sentinel lymph node melanoma patients.
Article in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Impact of melanoma histological regression on first-line immunotherapy response in stage-IV disease.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Article
- Deciphering the immune reaction leading to spontaneous melanoma regression: initial role of MHCIICancer immunology, immunotherapy : CII · 2023Article
- Associations of advanced age with comorbidity, stage and primary subsite as contributors to mortality from colorectal cancer.Frontiers in public health · 2023Article
- Histological regression in melanoma: impact on sentinel lymph node status and survival.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Coexistence of regression and tumor infiltrating lymphocytes is associated with more favorable survival in melanoma.Journal of cancer research and clinical oncology · 2021Article
- Reporting regression with melanoma in situ: reappraisal of a potential paradox.Archives of dermatological research · 2021Review
- Clinicopathologic Features of Cutaneous Malignant Melanoma and Their Impact on Prognosis.Cureus · 2020Article
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13 authors.
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Abstract
backgroundSentinel lymph node (SLN)-positive melanoma patients are a heterogeneous group of patients with survival rates ranging from ∼20 to over 80%. No data are reported concerning the role of histological regression on survival in stage III melanoma.
methodsThe study included 365 patients with positive SLN from two distinct hospitals. The model was developed on patients from 'AOU Città della Salute e della Scienza di Torino', and externally validated on patients from IRCCS of Candiolo. Survival analyses were carried out according to the presence of regression and adjusted for all other prognostic factors.
resultsAmong patients followed at 'AOU Città della Salute e della Scienza di Torino' (n=264), the median follow-up time to death or censoring (whatever two events occurred earlier) was 2.7 years since diagnosis (interquartile range: 1.3-5.8). In all, 79 patients died from melanoma and 11 from other causes. Histological regression (n=43) was associated with a better prognosis (sub-HR=0.34, CI 0.12-0.92), whereas the other factors above showed an inverse association. In the external validation, the concordance index was 0.97 at 1 year and decreased to 0.66 at 3 years and to 0.59 at 5 years. Adding histological regression in the prognostic model increased the discriminative ability to 0.75 at 3 years and to 0.62 at 5 years. Finally, using a cutoff of 20% for the risk of death led to a net re-classification improvement of 15 and 11% at 3 and 5 years after diagnosis, respectively.
conclusionsHistological regression could lead to an improvement in prognostic prediction in patients with stage III-positive SLN melanoma.
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