Evidence map›Paper›PMID 29123225›Full record

ReviewNature reviews. Microbiology2017

Archaea and the origin of eukaryotes.

Laura Eme, Anja Spang, Jonathan Lombard, Courtney W Stairs, Thijs J G Ettema

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 234 papers.

0numbers the graph read from it
0cells of the map it votes in
234citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

234 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Diversity of Archaea.Progress in molecular and subcellular biology · 2026
    Review
  15. Archaeal RNA processing and regulation: expanding the functional landscape.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  16. Regulation of eukaryotic-like cell cycle progression in archaea is coming into focus.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Article

174 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Laura EmeDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Box 596, Uppsala SE-75123, Sweden.
Anja SpangDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Box 596, Uppsala SE-75123, Sweden.
Jonathan LombardDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Box 596, Uppsala SE-75123, Sweden.
Courtney W StairsDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Box 596, Uppsala SE-75123, Sweden.
Thijs J G EttemaDepartment of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Box 596, Uppsala SE-75123, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Woese and Fox's 1977 paper on the discovery of the Archaea triggered a revolution in the field of evolutionary biology by showing that life was divided into not only prokaryotes and eukaryotes. Rather, they revealed that prokaryotes comprise two distinct types of organisms, the Bacteria and the Archaea. In subsequent years, molecular phylogenetic analyses indicated that eukaryotes and the Archaea represent sister groups in the tree of life. During the genomic era, it became evident that eukaryotic cells possess a mixture of archaeal and bacterial features in addition to eukaryotic-specific features. Although it has been generally accepted for some time that mitochondria descend from endosymbiotic alphaproteobacteria, the precise evolutionary relationship between eukaryotes and archaea has continued to be a subject of debate. In this Review, we outline a brief history of the changing shape of the tree of life and examine how the recent discovery of a myriad of diverse archaeal lineages has changed our understanding of the evolutionary relationships between the three domains of life and the origin of eukaryotes. Furthermore, we revisit central questions regarding the process of eukaryogenesis and discuss what can currently be inferred about the evolutionary transition from the first to the last eukaryotic common ancestor.

Indexed as

Biological EvolutionArchaeaEukaryotaPharmacogenomic Variants

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.