ArticleScientific reports2017
Liprotides kill cancer cells by disrupting the plasma membrane.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Albumin Nanoparticle-Based Delivery of Oxaliplatin-Oleic Acid Prodrug for Enhanced Breast Cancer Therapy.AAPS PharmSciTech · 2026Article
- ANXA6: a key molecular player in cancer progression and drug resistance.Discover oncology · 2023Review
- Biomedical Relevance of Novel Anticancer Peptides in the Sensitive Treatment of Cancer.Biomolecules · 2021Review
- The mosquito protein AEG12 displays both cytolytic and antiviral properties via a common lipid transfer mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Repairing plasma membrane damage in regulated necrotic cell death.Molecular biology reports · 2021Review
- α-Lactalbumin, Amazing Calcium-Binding Protein.Biomolecules · 2020Review
- The human milk protein-lipid complex HAMLET disrupts glycolysis and induces death inThe Journal of biological chemistry · 2019Article
- A Protein Complex from Human Milk Enhances the Activity of Antibiotics and Drugs againstAntimicrobial agents and chemotherapy · 2019Article
- Using Liprotides to Deliver Cholesterol to the Plasma Membrane.The Journal of membrane biology · 2018Article
- The Use of Human, Bovine, and Camel Milk Albumins in Anticancer Complexes with Oleic Acid.The protein journal · 2018Article
- Functional Association between Regulatory RNAs and the Annexins.International journal of molecular sciences · 2018Review
- BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state.PloS one · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HAMLET (human α-lactalbumin made lethal to tumour cells) is a complex of α-lactalbumin (aLA) and oleic acid (OA) which kills transformed cells, while leaving fully differentiated cells largely unaffected. Other protein-lipid complexes show similar anti-cancer potential. We call such complexes liprotides. The cellular impact of liprotides, while intensely investigated, remains unresolved. To address this, we report on the cell-killing mechanisms of liprotides prepared by incubating aLA with OA for 1 h at 20 or 80 °C (lip20 and lip80, respectively). The liprotides showed similar cytotoxicity against MCF7 cells, though lip80 acts more slowly, possibly due to intermolecular disulphide bonds formed during preparation. Liprotides are known to increase the fluidity of a membrane and transfer OA to vesicles, prompting us to focus on the effect of liprotides on the cell membrane. Extracellular Ca
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.