ArticleScientific reports2017
Zinc is a critical regulator of placental morphogenesis and maternal hemodynamics during pregnancy in mice.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Maternal serum zinc level is associated with risk of preeclampsia: A systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- Maternal Serum Zinc Level and Pre-eclampsia Risk in African Women: a Systematic Review and Meta-analysis.Biological trace element research · 2021Pooled it
- Effects of Maternal Zinc Deficiency and Post-Weaning Zinc Status on Neuroendocrine Markers Associated with Pubertal Regulation in Female Rat Offspring.International journal of molecular sciences · 2026Article
- Endometrial zinc transporterPNAS nexus · 2025Article
- Obesogenic Diet in Mice Leads to Inflammation and Oxidative Stress in the Mother in Association with Sex-Specific Changes in Fetal Development, Inflammatory Markers and Placental Transcriptome.Antioxidants (Basel, Switzerland) · 2024Article
- Review
- Relationships between the Content of Micro- and Macroelements in Animal Samples and Diseases of Different Etiologies.Animals : an open access journal from MDPI · 2023Article
- Effects of copper, zinc, and manganese source and inclusion during late gestation on beef cow-calf performance, mineral transfer, and metabolism.Translational animal science · 2023Article
- Role of zinc in female reproduction.Biology of reproduction · 2021Review
- Zinc in Dog Nutrition, Health and Disease: A Review.Animals : an open access journal from MDPI · 2021Review
- Preconceptional Lipid-Based Nutrient Supplementation in 2 Low-Resource Countries Results in Distinctly Different IGF-1/mTOR Placental Responses.The Journal of nutrition · 2021Article
- Zinc.Advances in food and nutrition research · 2021Review
- Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition.Frontiers in cell and developmental biology · 2021Review
- Impacts of Bovine Trace Mineral Supplementation on Maternal and Offspring Production and Health.Animals : an open access journal from MDPI · 2020Review
- Insulin-regulated aminopeptidase deficiency impairs cardiovascular adaptations and placental development during pregnancy.Clinical science (London, England : 1979) · 2020Article
- The Role of Fe, Zn, and Cu in Pregnancy.Biomolecules · 2020Review
- Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review.Frontiers in molecular neuroscience · 2020Article
- Characterization of 5-methylcytosine and 5-hydroxymethylcytosine in human placenta cell types across gestation.Epigenetics · 2019Article
- Identification of novel candidate indicators for assessing zinc status during pregnancy in mice from microarray data.BMC pharmacology & toxicology · 2019Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zinc is an essential micronutrient in pregnancy and zinc deficiency impairs fetal growth. We used a mouse model of moderate zinc deficiency to investigate the physiological mechanisms by which zinc is important to placental morphogenesis and the maternal blood pressure changes during pregnancy. A 26% reduction in circulating zinc (P = 0.005) was exhibited in mice fed a moderately zinc-deficient diet. Zinc deficiency in pregnancy resulted in an 8% reduction in both near term fetal and placental weights (both P < 0.0001) indicative of disrupted placental development and function. Detailed morphological analysis confirmed changes to the placental labyrinth microstructure. Continuous monitoring of maternal mean arterial pressure (MAP) revealed a late gestation decrease in the zinc-deficient dams. Differential expression of a number of regulatory genes within maternal kidneys supported observations on MAP changes in gestation. Increased MAP late in gestation is required to maintain perfusion of multiple placentas within rodent pregnancies. Decreased MAP within the zinc-deficient dams implies reduced blood flow and nutrient delivery to the placenta. These findings show that adequate zinc status is required for correct placental morphogenesis and appropriate maternal blood pressure adaptations to pregnancy. We conclude that insufficient maternal zinc intake from before and during pregnancy is likely to impact in utero programming of offspring growth and development largely through effects to the placenta and maternal cardiovascular system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.