ArticleNature communications2017
A mechanism for FtsZ-independent proliferation in Streptomyces.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed.
- A histidine pseudokinase modulates polar growth and cell shape in Streptomyces venezuelae.Communications biology · 2026Article
- A dispensable SepIVA orthologue in Streptomyces venezuelae is associated with polar growth and not cell division.BMC microbiology · 2024Article
- What is the role of microbial biotechnology and genetic engineering in medicine?MicrobiologyOpen · 2024Review
- The Best of Both Worlds-Streptomyces coelicolor and Streptomyces venezuelae as Model Species for Studying Antibiotic Production and Bacterial Multicellular Development.Journal of bacteriology · 2023Review
- Characterization ofMicroorganisms · 2023Article
- Global Regulator AdpA_1075 Regulates Morphological Differentiation and Ansamitocin Production inBioengineering (Basel, Switzerland) · 2022Article
- Hyphal compartmentalization and sporulation in Streptomyces require the conserved cell division protein SepX.Nature communications · 2022Article
- Article
- Influence of core divisome proteins on cell division inMicrobiology (Reading, England) · 2021Article
- Microbial Musings - February 2021.Microbiology (Reading, England) · 2021Article
- The Antitumor Agent Ansamitocin P-3 Binds to Cell Division Protein FtsZ inBiomolecules · 2020Article
- Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation.Cell chemical biology · 2019Article
- The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes.Nature communications · 2019Article
- Turgor Pressure and Possible Constriction Mechanisms in Bacterial Division.Frontiers in microbiology · 2018Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The central player in bacterial cell division, FtsZ, is essential in almost all organisms in which it has been tested, with the most notable exception being Streptomyces. Streptomycetes differ from many bacteria in growing from the cell tip and undergoing branching, similar to filamentous fungi. Here we show that limited cell damage, either mechanical or enzymatic, leads to near complete destruction of mycelial microcolonies of a Streptomyces venezuelae ftsZ mutant. This result is consistent with a lack of ftsZ-dependent cross-walls and may be inconsistent with a recently proposed role for membrane structures in the proliferation of ftsZ mutants in other Streptomyces species. Rare surviving fragments of mycelium, usually around branches, appear to be the preferred sites of resealing. Restoration of growth in hyphal fragments of both wild-type and ftsZ mutant hyphae can occur at multiple sites, via branch-like outgrowths containing DivIVA protein at their tips. Thus, our results highlight branching as a means of FtsZ-independent cell proliferation.
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Registered trials
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