Evidence map›Paper›PMID 29123104›Full record

Trial reportScientific reports2017

A Prospective, Randomized Trial of Two Mucin Secretogogues for the Treatment of Dry Eye Syndrome in Office Workers.

Jun Shimazaki, Den Seika, Masamichi Saga, Kazumi Fukagawa, Miki Sakata, Miki Iwasaki, Takashi Okano

Open access · goldAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jun ShimazakiDepartment of Ophthalmology, Tokyo Dental College Ichikawa General Hospital, Chiba, Japan. jun@eyebank.or.jp.
Den SeikaShimazaki Eye Clinic, Tokyo, Japan.
Masamichi SagaIchikawa Shapo Eye Clinic, Chiba, Japan.
Kazumi FukagawaRyogoku Eye Clinic, Tokyo, Japan.
Miki SakataShinjuku Eye Clinic, Tokyo, Japan.
Miki IwasakiRyogoku Eye Clinic, Tokyo, Japan.
Takashi OkanoSmile Eye Clinic, Yokohama, Japan.
Minamiaoyama Eye Clinic · JPTokyo Dental College Ichikawa General Hospital · JPRyogoku High School · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of the study was to compare the two mucin secretogogues, diquafosol (DQS) and rebamipide (RBM), for the treatment of dry eye syndrome (DES) in office workers. Dry eye patients using computers for >4 h/day were randomly assigned treatment with either DQS or RBM. Main outcomes measures included changes in tear film break-up time (TBUT) and subjective symptoms assessed by the Dry Eye-Related Quality of Life Score (DEQS). The subjects had scheduled examinations at 0 and 4 weeks, and the examinations at 2 and 8 weeks were optional. Changes in keratoconjunctival fluorescein score and a patient satisfaction questionnaire were also recorded. Both groups showed significant improvements in the DEQS scores at 2, 4, and 8 weeks following the initiation of the study. Both groups showed significant increases in the TBUT at 2 and 4 weeks. No significant difference was found between the DQS and RBM groups at any time periods. Patients reported more comfort with the use of DQS compared with the use of RBM. No local or systemic side effects were noted. The results of the present study indicated that both DQS and RBM were effective for the treatment of DES in office workers.

Indexed as

AdultAlanineConjunctivaDry Eye SyndromesFemaleHumansMaleMiddle AgedOccupational DiseasesPolyphosphatesProspective StudiesQuality of LifeQuinolonesScleraSecretagoguesSurveys and QuestionnairesAlaninediquafosolPolyphosphatesQuinolonesrebamipideSecretagoguesUracil Nucleotides

Identifiers

PMID29123104
PMCPMC5680274
OpenAlexW2766771261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.