ArticleJournal of epidemiology and community health2018
Childhood psychosocial adversity and female reproductive timing: a cohort study of the ALSPAC mothers.
Article in Journal of epidemiology and community health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Adverse Childhood Experiences and Early Pubertal Timing Among Girls: A Meta-Analysis.International journal of environmental research and public health · 2019Pooled it
- The association between age at menarche and subsequent risk of chronic pain.Frontiers in global women's health · 2026Review
- Adverse childhood experiences, age at menopause, and vasomotor symptoms among mid-life Latine adults in California.Evolutionary human sciences · 2026Article
- Associations of In Utero Exposure to Racial Violence and Reproductive Development: The Bogalusa Heart Study.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Bone Fracture History in Women With First Episode or With Persistent Anorexia Nervosa.European eating disorders review : the journal of the Eating Disorders Association · 2025Article
- Sexual experiences and behaviours of the parents in the Avon Longitudinal Study of Parents and Childhood (ALSPAC).Wellcome open research · 2024Article
- Causal associations between female reproductive behaviors and psychiatric disorders: a lifecourse Mendelian randomization study.BMC psychiatry · 2023Article
- Article
- Early puberty paradox: an investigation of anxiety levels of mothers and children, children's quality of life, and psychiatric diagnoses.European journal of pediatrics · 2023Article
- Precocious puberty under stressful conditions: new understanding and insights from the lessons learnt from international adoptions and the COVID-19 pandemic.Frontiers in endocrinology · 2023Review
- Family environmental antecedents of pubertal timing in girls and boys: A review and open questions.Hormones and behavior · 2022Review
- Epigenetic regulation of 5α reductase-1 underlies adaptive plasticity of reproductive function and pubertal timing.BMC biology · 2022Article
- Social and Biological Transgenerational Underpinnings of Adolescent Pregnancy.International journal of environmental research and public health · 2021Review
- Influence of Childhood Adversity and Infection on Timing of Menarche in a Multiethnic Sample of Women.International journal of environmental research and public health · 2021Article
- Germ Cell Drivers: Transmission of Preconception Stress Across Generations.Frontiers in human neuroscience · 2021Review
- Association of Early-Life Adversity With Measures of Accelerated Biological Aging Among Children in China.JAMA network open · 2020Article
- Timing of menarche and self-harm in adolescence and adulthood: a population-based cohort study.Psychological medicine · 2020Article
- Unravelling the role of epigenetics in reproductive adaptations to early-life environment.Nature reviews. Endocrinology · 2020Review
- Adverse childhood experiences are associated with increased risk of miscarriage in a national population-based cohort study in England.Human reproduction (Oxford, England) · 2020Article
- Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study.BMC medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundPrevious studies of childhood psychosocial adversity and age at menarche mostly evaluated single or a few measures of adversity, and therefore could not quantify total psychosocial adversity. Limited knowledge is currently available regarding childhood psychosocial adversity in relation to age at menopause and reproductive lifespan.
methodsWe examined the associations of total and specific components of childhood psychosocial adversity with age at menarche (n=8984), age at menopause (n=945), and length of reproductive lifespan (n=841), in mothers participating in the Avon Longitudinal Study of Parents and Children. We used confirmatory factor analysis to characterise lack of care, maladaptive family functioning, non-sexual abuse, overprotective parenting, parental mental illness and sexual abuse. These specific components of childhood psychosocial adversity were combined into a total psychosocial adversity score using a second-order factor analysis. We used structural equation models to simultaneously conduct the factor analysis and estimate the association with the continuous outcomes of interest.
resultsTotal childhood psychosocial adversity was not associated with age at menarche, age at menopause or length of reproductive lifespan. When we examined the separate psychosocial adversity constructs, sexual abuse was inversely associated with age at menarche, with a mean difference of -0.17 (95% CI -0.23 to -0.12) years per SD higher factor score, and with age at menopause, with a mean difference of -0.17 (95% CI -0.52 to 0.18) per SD higher factor score.
conclusionChildhood sexual abuse was associated with lower age at menarche and menopause, but the latter needs to be confirmed in larger samples.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.