Evidence map›Paper›PMID 29122984›Full record

ArticleJournal of cell science2017

Effects of mutating α-tubulin lysine 40 on sensory dendrite development.

Brian V Jenkins, Harriet A J Saunders, Helena L Record, Dena M Johnson-Schlitz, Jill Wildonger

Open access · hybridAbstract read
In one paragraph

Article in Journal of cell science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 48 citations in OpenAlex.

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  9. Live Imaging of Golgi Outposts in Drosophila Dendritic Arbors.Methods in molecular biology (Clifton, N.J.) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Brian V JenkinsBiochemistry Department, University of Wisconsin-Madison, Madison, WI 53706, USA.
Harriet A J SaundersBiochemistry Department, University of Wisconsin-Madison, Madison, WI 53706, USA.
Helena L RecordBiochemistry Department, University of Wisconsin-Madison, Madison, WI 53706, USA.
Dena M Johnson-SchlitzBiochemistry Department, University of Wisconsin-Madison, Madison, WI 53706, USA.
Jill WildongerBiochemistry Department, University of Wisconsin-Madison, Madison, WI 53706, USA wildonger@wisc.edu.ORCID http://orcid.org/0000-0002-6462-5830
University of Wisconsin–Madison · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
ROLE OF MICROTUBULE-BASED TRANSPORT IN NEURONAL POLARITYR00NS072252 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI WILDONGER, JILL C · 2012 to 2014
$729k
Multi-scale analysis and modeling of acetylation effects on neuronal microtubulesR21NS101553 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI GARDNER, MELISSA, WILDONGER, JILL C · 2017 to 2018
$422k
NIH HHS P40 OD018537NINDS NIH HHS R00 NS072252NINDS NIH HHS R21 NS101553
6 · The paper itself

Abstract

Microtubules are essential for neuronal structure and function. Axonal and dendritic microtubules are enriched in post-translational modifications that impact microtubule dynamics, transport and microtubule-associated proteins. Acetylation of α-tubulin lysine 40 (K40) is a prominent and conserved modification of neuronal microtubules. However, the cellular role of microtubule acetylation remains controversial. To resolve how microtubule acetylation might affect neuronal morphogenesis, we mutated endogenous α-tubulin

Indexed as

AcetylationAnimalsDendritesDrosophila melanogasterLysineMicrotubulesMorphogenesisMutationNeurogenesisProtein Processing, Post-TranslationalSensory Receptor CellsTubulinLysineTubulinAcetylationDendriteDrosophilaMicrotubuleNeuron

Identifiers

PMID29122984
PMCPMC5769580
OpenAlexW2767016970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.