Evidence map›Paper›PMID 29122977›Full record

ArticleJournal of lipid research2018

Aβ inhibits SREBP-2 activation through Akt inhibition.

Amany Mohamed, Anissa Viveiros, Kathleen Williams, Elena Posse de Chaves

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
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  3. Review
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  7. Article
  8. Investigation of Potential Drug Targets for Cholesterol Regulation to Treat Alzheimer's Disease.International journal of environmental research and public health · 2023
    Article
  9. Artesunate targets cellular metabolism to regulate the Th17/Treg cell balance.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Review
  10. Review
  11. Review
  12. Intracellular Cholesterol Synthesis and Transport.Frontiers in cell and developmental biology · 2022
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Amany MohamedDepartment of Pharmacology and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.
Anissa ViveirosDepartment of Pharmacology and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.
Kathleen WilliamsDepartment of Pharmacology and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.
Elena Posse de ChavesDepartment of Pharmacology and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada elena.chaves@ualberta.ca.
University of Alberta · CAWomen and Children’s Health Research Institute · CA

Funding

CIHR MOP 93738
6 · The paper itself

Abstract

We previously demonstrated that oligomeric amyloid β

Indexed as

Amyloid beta-PeptidesAnimalsApoptosisCells, CulturedFemaleMaleNeuronsPeptide FragmentsProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySterol Regulatory Element Binding Protein 2Amyloid beta-Peptidesamyloid beta-protein (1-42)Peptide FragmentsProto-Oncogene Proteins c-aktSterol Regulatory Element Binding Protein 2Alzheimer’s diseaseamyloid βcholesterol/biosynthesischolesterol/traffickingisoprenoidsneuronsnuclear receptors/sterol regulatory element-binding proteinoligomeric amyloid β42prenylationprotein kinase Bsterol regulatory element-binding protein-2

Identifiers

PMID29122977
PMCPMC5748492
OpenAlexW2781616213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.