Evidence map›Paper›PMID 29122948›Full record

ArticleThe Journal of experimental medicine2017

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.

Priti B Singh, Heather H Pua, Hannah C Happ, Christoph Schneider, Jakob von Moltke, Richard M Locksley, Dirk Baumjohann, K Mark Ansel

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Regulation of noncoding RNAs in innate lymphoid cells.Cellular & molecular immunology · 2023
    Article
  6. Review
  7. Review
  8. Review
  9. Frontiers in microbiology · 2023
    Article
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  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Priti B SinghDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA.
Heather H PuaDepartment of Pathology, University of California, San Francisco, San Francisco, CA.ORCID http://orcid.org/0000-0002-9271-2608
Hannah C HappDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA.ORCID http://orcid.org/0000-0002-8266-266X
Christoph SchneiderDepartment of Medicine, University of California, San Francisco, San Francisco, CA.
Jakob von MoltkeDepartment of Medicine, University of California, San Francisco, San Francisco, CA.ORCID http://orcid.org/0000-0003-2894-3353
Richard M LocksleyDepartment of Medicine, University of California, San Francisco, San Francisco, CA.
Dirk BaumjohannInstitute for Immunology, Biomedical Center Munich, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.ORCID http://orcid.org/0000-0001-8385-8288
K Mark AnselDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA mark.ansel@ucsf.edu.ORCID http://orcid.org/0000-0003-4840-9879
University of California, San Francisco · USHoward Hughes Medical Institute · USLudwig-Maximilians-Universität München · DE

Funding

Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2012 to 2023
$23.3M
Transcellular epigenetic regulation by ex-small RNA in C. elegantU19CA179512 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BLELLOCH, ROBERT · 2013 to 2017
$7.4M
Role of miRNAs in Th2-Driven inflammation in AsthmaR01HL109102 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Karl Mark Ansel · 2011 to 2026
$5.5M
Parasite immunity orchestrated by type 2 immune cellsR01AI026918 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 1988 to 2022
$3.8M
MicroRNA-23 Cluster Regulation of Helper T cell Differentiation and FunctionK08AI116949 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PUA, HEATHER H · 2015 to 2019
$828k
NCI NIH HHS U19 CA179512NHLBI NIH HHS P01 HL107202NHLBI NIH HHS R01 HL109102NIAID NIH HHS K08 AI116949NIAID NIH HHS R01 AI026918
6 · The paper itself

Abstract

MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation. We established the physiological requirements for miRNAs in ILC2 homeostasis and immune function and compared the global miRNA repertoire of resting and activated ILC2s and T helper type 2 (T

Indexed as

AnimalsCell ProliferationCytokinesGene Expression RegulationHomeostasisHypersensitivityImmunity, InnateInflammationLymphocytesMice, Inbred C57BLMicroRNAsSequence Analysis, RNASuppressor of Cytokine Signaling 1 ProteinTh2 CellsTumor Necrosis Factor alpha-Induced Protein 3CytokinesMicroRNAsSocs1 protein, mouseSuppressor of Cytokine Signaling 1 ProteinTnfaip3 protein, mouseTumor Necrosis Factor alpha-Induced Protein 3

Identifiers

PMID29122948
PMCPMC5716040
OpenAlexW2779943078

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.