ArticleHeart (British Cardiac Society)2018
Diagnostic performance of an acoustic-based system for coronary artery disease risk stratification.
Article in Heart (British Cardiac Society), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dan-NICAD - Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease
Chronic Coronary Syndrome in Swedish Primary Care
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Diagnostic performance of coronary artery disease prediction model (CAD-score system) based on phonocardiogram: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Acoustic-based rule-out of stable coronary artery disease: the FILTER-SCAD trial.European heart journal · 2025Trial
- Diagnostic performance of a device for acoustic heart sound analysis in patients with suspected myocardial infarction.Open heart · 2023Trial
- Extraction of Acoustic Features via Empirical Wavelet Transform to Determine Stenosis Degree of the Left Anterior Descending Artery Based on the Diastolic Heart Sounds of 75 Participants.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Article
- Coronary artery disease diagnosis with signal processing and machine learning of heart sound signals: a systematic review.NPJ digital medicine · 2026Article
- Optimizing diagnostic resource use in suspected chronic coronary syndrome: pre-test probability and acoustic CAD rule-out in the FILTER-SCAD trial.European heart journal. Digital health · 2026Article
- Photoacoustic spectroscopy detection based on complementary interdigital cantilever enhanced Fabry-Perot acoustic sensor.Photoacoustics · 2025Article
- Cost-Effectiveness of the CADScor System in Low-Risk Patients Presenting to the Emergency Department with Chest Pain.PharmacoEconomics - open · 2025Article
- Article
- Pre-test probability estimation of coronary artery disease can be improved by adding an acoustic-based risk score.International journal of cardiology. Heart & vasculature · 2025Article
- Deep learning of heart-sound signals for efficient prediction of obstructive coronary artery disease.Heliyon · 2024Article
- Improved pre-test likelihood estimation of coronary artery disease using phonocardiography.European heart journal. Digital health · 2022Article
- Subtle QRS changes are associated with reduced ejection fraction, diastolic dysfunction, and heart failure development and therapy responsiveness: Applications for artificial intelligence to ECG.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022Review
- The Feasibility of Ultra-Sensitive Phonocardiography in Acute Chest Pain Patients of a Tertiary Care Emergency Department (ScorED Feasibility Study).Journal of personalized medicine · 2022Article
- Economic Analysis of the CADScor System for Ruling Out Coronary Artery Disease in England.PharmacoEconomics - open · 2022Article
- Development and validation of a machine learned algorithm to IDENTIFY functionally significant coronary artery disease.Frontiers in cardiovascular medicine · 2022Article
- Improvement of the Accuracy in the Identification of Coronary Artery Disease Combining Heart Sound Features.BioMed research international · 2022Article
- Article
- Prospective validation of an acoustic-based system for the detection of obstructive coronary artery disease in a high-prevalence population.Heart and vessels · 2021Article
- Advanced heart sound analysis as a new prognostic marker in stable coronary artery disease.European heart journal. Digital health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDiagnosing coronary artery disease (CAD) continues to require substantial healthcare resources. Acoustic analysis of transcutaneous heart sounds of cardiac movement and intracoronary turbulence due to obstructive coronary disease could potentially change this. The aim of this study was thus to test the diagnostic accuracy of a new portable acoustic device for detection of CAD.
methodsWe included 1675 patients consecutively with low to intermediate likelihood of CAD who had been referred for cardiac CT angiography. If significant obstruction was suspected in any coronary segment, patients were referred to invasive angiography and fractional flow reserve (FFR) assessment. Heart sound analysis was performed in all patients. A predefined acoustic CAD-score algorithm was evaluated; subsequently, we developed and validated an updated CAD-score algorithm that included both acoustic features and clinical risk factors. Low risk is indicated by a CAD-score value ≤20.
resultsHaemodynamically significant CAD assessed from FFR was present in 145 (10.0%) patients. In the entire cohort, the predefined CAD-score had a sensitivity of 63% and a specificity of 44%. In total, 50% had an updated CAD-score value ≤20. At this cut-off, sensitivity was 81% (95% CI 73% to 87%), specificity 53% (95% CI 50% to 56%), positive predictive value 16% (95% CI 13% to 18%) and negative predictive value 96% (95% CI 95% to 98%) for diagnosing haemodynamically significant CAD.
conclusionSound-based detection of CAD enables risk stratification superior to clinical risk scores. With a negative predictive value of 96%, this new acoustic rule-out system could potentially supplement clinical assessment to guide decisions on the need for further diagnostic investigation. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov identifier NCT02264717; Results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.