Evidence map›Paper›PMID 29122854›Full record

ArticleG3 (Bethesda, Md.)2018

The Substrates of Nonsense-Mediated mRNA Decay in

Virginia S Muir, Audrey P Gasch, Philip Anderson

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. piRNAs safeguard splicing and RNA fidelity during heat shock.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Pathways that affect anterior morphogenesis inbioRxiv : the preprint server for biology · 2023
    Article
  10. Article
  11. mThe EMBO journal · 2021
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Virginia S MuirLaboratory of Genetics, University of Wisconsin-Madison, Wisconsin 53706 andersn@wisc.edu.
Audrey P GaschLaboratory of Genetics, University of Wisconsin-Madison, Wisconsin 53706.
Philip AndersonLaboratory of Genetics, University of Wisconsin-Madison, Wisconsin 53706 andersn@wisc.edu.
University of Wisconsin–Madison · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
GENETIC &MOLECULAR STUDIES OF NEMATODE MRNA DEGRADATIONR01GM050933 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ANDERSON, PHILIP · 1994 to 2011
$4.0M
Functional Genomics of Stress Defense in YeastR01GM083989 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI GASCH, AUDREY · 2008 to 2016
$3.0M
NIGMS NIH HHS R01 GM050933NIGMS NIH HHS R01 GM083989NIGMS NIH HHS T32 GM007133
6 · The paper itself

Abstract

Nonsense-mediated mRNA decay (NMD) is a conserved pathway that strongly influences eukaryotic gene expression. Inactivating or inhibiting NMD affects the abundance of a substantial fraction of the transcriptome in numerous species. Transcripts whose abundance is altered in NMD-deficient cells may represent either direct substrates of NMD or indirect effects of inhibiting NMD. We present a genome-wide investigation of the direct substrates of NMD in

Indexed as

Genome, HelminthNonsense Mediated mRNA DecayRNA SplicingTranscriptomeAnimalsBiological EvolutionCaenorhabditis elegansCaenorhabditis elegans ProteinsCodon, NonsenseHigh-Throughput Nucleotide SequencingProtein BiosynthesisPseudogenesRNA, MessengerCaenorhabditis elegans ProteinsCodon, NonsenseRNA, MessengerSMG-2 protein, C elegansC. elegansNonsense-mediated mRNA decay (NMD)post-transcriptional gene regulationRNA-SeqUPF1/SMG-2

Identifiers

PMID29122854
PMCPMC5765348
OpenAlexW2767231507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.