Evidence map›Paper›PMID 29122812›Full record

ArticleJournal of the American Heart Association2017

Nebivolol, But Not Metoprolol, Treatment Improves Endothelial Fibrinolytic Capacity in Adults With Elevated Blood Pressure.

Brian L Stauffer, Caitlin A Dow, Kyle J Diehl, Tyler D Bammert, Jared J Greiner, Christopher A DeSouza

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01595516 (Nebivolol and Endothelial Regulation of Fibrinolysis), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01595516 phase4completednot on this map

Nebivolol and Endothelial Regulation of Fibrinolysis

TypeinterventionalSponsorUniversity of Colorado, BoulderRan2012 to 2017Enrolled44ConditionsPrehypertension, HypertensionArmsNebivolol, Metoprolol, Placebo, Bradykinin, Saline
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Brian L StaufferIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO brian.stauffer@ucdenver.edu.
Caitlin A DowIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO.
Kyle J DiehlIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO.
Tyler D BammertIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO.
Jared J GreinerIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO.
Christopher A DeSouzaIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO.
University of Colorado Boulder · USIntegrative Medicine Institute · USUniversity of Colorado Denver · US

Funding

POSTGRADUATE TRAINING IN CARDIOVASCULAR RESEARCHT32HL007822 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUTTRICK, PETER N., LEINWAND, LESLIE ANNE · 1996 to 2023
$6.2M
NHLBI NIH HHS T32 HL007822
6 · The paper itself

Abstract

backgroundVascular endothelial fibrinolytic function is impaired in adults with prehypertension and hypertension and plays a mechanistic role in the development of atherothrombotic events. The influence of β-blockers on endothelial fibrinolysis is unknown. This study compared the effects of chronic nebivolol and metoprolol treatment on endothelial tissue-type plasminogen activator (t-PA) release in adults with elevated blood pressure (BP). METHODS AND

resultsForty-four middle-aged adults (36% women) with elevated BP completed a 3-month, double-blind, randomized, placebo-controlled trial comparing nebivolol (5 mg/d), metoprolol succinate (100 mg/d), and placebo. Net endothelial t-PA release was determined in vivo in response to intrabrachial infusions of bradykinin and sodium nitroprusside before and after each intervention. In a subset, the dose-response curves to bradykinin and sodium nitroprusside were repeated with a coinfusion of the antioxidant vitamin C. At baseline, resting BP and endothelial t-PA release were comparable between the 3 groups. BP decreased to a similar extent (≈10 mm Hg) in the nebivolol- and metoprolol-treated groups. There was a substantial increase (≈30%;

conclusionsNebivolol but not metoprolol improves endothelial t-PA release in adults with elevated BP. This may be an important vascular benefit of nebivolol. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01595516.

Indexed as

Adrenergic beta-1 Receptor AntagonistsBlood PressureDose-Response Relationship, DrugDouble-Blind MethodEndothelium, VascularFemaleFibrinolysisFollow-Up StudiesHumansHypertensionMaleMetoprololMiddle AgedNebivololTreatment OutcomeVasodilator AgentsAdrenergic beta-1 Receptor AntagonistsMetoprololNebivololVasodilator Agentshypertensionmetoprololnebivololoxidative stresstissue‐type plasminogen activatorvitamin C

Identifiers

PMID29122812
PMCPMC5721799
OpenAlexW2767391531

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.