ArticleBMJ open2017
Consensus validation of the POSAMINO (POtentially Serious Alcohol-Medication INteractions in Older adults) criteria.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Association of alcohol consumption with morbidity and mortality in patients with cardiovascular disease: original data and meta-analysis of 48,423 men and women.BMC medicine · 2021Pooled it
- Pooled it
- A scoping review of quality prescribing indicators, rules and criteria for primary care.British journal of clinical pharmacology · 2026Article
- Sex Differences in Older Adults with Risky Alcohol Consumption: Medication Use, Comorbidities, and Hepatic Biomarkers.Nutrients · 2026Article
- Ethanol as a Modifier of Drug Toxicity in Humans: Pathways of Toxicity and Organ-Level Consequences.International journal of molecular sciences · 2026Review
- Questions on Medicines, Alcohol, and Illicit Drug Interactions in the Finnish AddictionLink Online Service: A Descriptive Analysis.Nordisk alkohol- & narkotikatidskrift : NAT · 2026Article
- Alcohol-medication interactions among older people: a narrative review on age-specific evidence.Alcohol and alcoholism (Oxford, Oxfordshire) · 2026Review
- Silent Dangers in Elderly Pharmacotherapy: The Interplay of Polypharmacy, Multimorbidity, and Drug Interactions.Journal of evaluation in clinical practice · 2025Review
- Priority indicators for evaluating the impact of field epidemiology training programs - results of a global modified Delphi study.BMC public health · 2025Article
- Drug safety in older patients with alcohol use disorder: a retrospective cohort study.Therapeutic advances in psychopharmacology · 2024Article
- Consensus recommendations for opioid agonist treatment following the introduction of emergency clinical guidelines in Ireland during the COVID-19 pandemic: A national Delphi study.The International journal on drug policy · 2022Article
- Structured medication reviews: origins, implementation, evidence, and prospects.The British journal of general practice : the journal of the Royal College of General Practitioners · 2021Article
- Alcohol consumption and risk of cardiovascular outcomes and bleeding in patients with established atrial fibrillation.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021Observational
- The association between medication or alcohol use and the incidence of frailty: a retrospective cohort study.BMC geriatrics · 2021Article
- Article
- Favorable Outcomes Following the Use of Triple Therapy in a Patient with Osmotic Demyelination Syndrome.Kansas journal of medicine · 2020Article
- Potentially serious alcohol-medication interactions and falls in community-dwelling older adults: a prospective cohort study.Age and ageing · 2019Article
- Longitudinal prevalence of potentially serious alcohol-medication interactions in community-dwelling older adults: a prospective cohort study.European journal of clinical pharmacology · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOlder adults are particularly vulnerable to adverse effects from concurrent alcohol and medication use. However, there is limited evidence regarding the prevalence of these adverse outcomes among older adults, and there is a lack of consensus regarding what constitutes an alcohol-interactive medicine. The objective of this study was to develop an explicit list of potentially serious alcohol-medication interactions for use in older adults.
designFollowing a systematic review, review of drug compendia and clinical guidance documents, a two-round Delphi consensus method was conducted.
settingIreland and the United Kingdom (UK), primary care and hospital setting.
participantsThe Project Steering Group developed a list of potentially serious alcohol-medication interactions. The Delphi panel consisted of 19 healthcare professionals (general practitioners, geriatricians, hospital and community pharmacists, clinical pharmacologists and pharmacists, and physicians specialising in substance misuse).
resultsAn inventory of 52 potentially serious alcohol-medication interactions was developed by the Project Steering Group. British National Formulary black dot warnings (n=8) were included in the final criteria as they represent 'potentially serious' interactions. The remaining 44 criteria underwent a two-round Delphi process. In the first round, 13 criteria were accepted into the POtentially Serious Alcohol-Medication INteractions in Older adults (POSAMINO) criteria. Consensus was not reached on the remaining 31 criteria; 9 were removed and 8 additional criteria were included following a review of panellist comments. The remaining 30 criteria went to round 2, with 17 criteria reaching consensus, providing a final list of 38 potentially serious alcohol-medication interactions: central nervous system (n=15), cardiovascular system (n=9), endocrine system (n=5), musculoskeletal system (n=3), infections (n=3), malignant disease and immunosuppression (n=2), and respiratory system (n=1).
conclusionsPOSAMINO is the first set of explicit potentially serious alcohol-medication interactions for use in older adults. Following future validation studies, these criteria may allow for the risk stratification of older adults at the point of prescribing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.