ArticleAJNR. American journal of neuroradiology2018
Spinal Cord Gray Matter Atrophy in Amyotrophic Lateral Sclerosis.
Article in AJNR. American journal of neuroradiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
- Cross-sectional relationships between spinal cord gray matter volume and pain in individuals with fibromyalgia and opioid use.Scientific reports · 2025Article
- Quantitative cervical cord MRI in spinal muscular atrophy: a sensitive imaging biomarker of disease evolution and treatment.Journal of neurology · 2025Article
- Semiautomated Pipeline Effectively Assesses Severity and Monitor Disease Progression in Compressed Spinal Cord of Degenerative Cervical Myelopathy Patients.Neurosurgery practice · 2025Article
- Review
- Cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis.European journal of neurology · 2024Article
- Quantitative brainstem and spinal MRI in amyotrophic lateral sclerosis: implications for predicting noninvasive ventilation needs.Journal of neurology · 2024Article
- DeepRetroMoCo: deep neural network-based retrospective motion correction algorithm for spinal cord functional MRI.Frontiers in psychiatry · 2024Article
- A database of the healthy human spinal cord morphometry in the PAM50 template space.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Association between brain and upper cervical spinal cord atrophy assessed by MRI and disease aggressiveness in amyotrophic lateral sclerosis.Neuroradiology · 2023Article
- Comparison of spinal magnetic resonance imaging and classical clinical factors in predicting motor capacity in amyotrophic lateral sclerosis.Journal of neurology · 2023Article
- Analysis of brain and spinal MRI measures in a common domain to investigate directional neurodegeneration in motor neuron disease.Journal of neurology · 2023Article
- Cervical spinal cord atrophy in amyotrophic lateral sclerosis across disease stages.Annals of clinical and translational neurology · 2023Article
- Optimized multi-echo gradient-echo magnetic resonance imaging for gray and white matter segmentation in the lumbosacral cord at 3 T.Scientific reports · 2022Article
- Generic acquisition protocol for quantitative MRI of the spinal cord.Nature protocols · 2021Article
- Spinal Cord Gray and White Matter Damage in Different Hereditary Spastic Paraplegia Subtypes.AJNR. American journal of neuroradiology · 2021Article
- Mapping the rest of the human connectome: Atlasing the spinal cord and peripheral nervous system.NeuroImage · 2021Review
- Brainstem Involvement in Amyotrophic Lateral Sclerosis: A Combined Structural and Diffusion Tensor MRI Analysis.Frontiers in neuroscience · 2021Article
- Article
- The upper cervical spinal cord in ALS assessed by cross-sectional and longitudinal 3T MRI.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThere is an emerging need for biomarkers to better categorize clinical phenotypes and predict progression in amyotrophic lateral sclerosis. This study aimed to quantify cervical spinal gray matter atrophy in amyotrophic lateral sclerosis and investigate its association with clinical disability at baseline and after 1 year. MATERIALS AND
methodsTwenty-nine patients with amyotrophic lateral sclerosis and 22 healthy controls were scanned with 3T MR imaging. Standard functional scale was recorded at the time of MR imaging and after 1 year. MR imaging data were processed automatically to measure the spinal cord, gray matter, and white matter cross-sectional areas. A statistical analysis assessed the difference in cross-sectional areas between patients with amyotrophic lateral sclerosis and controls, correlations between spinal cord and gray matter atrophy to clinical disability at baseline and at 1 year, and prediction of clinical disability at 1 year.
resultsGray matter atrophy was more sensitive to discriminate patients with amyotrophic lateral sclerosis from controls (
conclusionsAlthough improvements over spinal cord cross-sectional areas were modest, this study suggests the potential use of gray matter cross-sectional areas as an MR imaging structural biomarker to monitor the evolution of amyotrophic lateral sclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.