Evidence map›Paper›PMID 29122679›Full record

ReviewMolecular aspects of medicine2018

Extracellular vesicles: Novel mediator for cell to cell communications in liver pathogenesis.

Pradip B Devhare, Ratna B Ray

Registry-linked trialAbstract readReview
In one paragraph

Review in Molecular aspects of medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05637931 (Evaluation of Circulating PlexinD1 as a Potential Biomarker of Polymyositis and Dermatomyositis.), which is not on this map. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05637931 unknown statusnot on this mapstarted 2022, after this paper: background citation

Evaluation of Circulating PlexinD1 as a Potential Biomarker of Polymyositis and Dermatomyositis.

TypeobservationalSponsorAssiut UniversityRan2022 to 2024Enrolled66ConditionsPolymyositis, DermatomyositisArmsplexinD1
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 113 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. [Regulatory effect ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
    Article
  17. Review
  18. Article
  19. Immunomodulatory properties ofFrontiers in parasitology · 2024
    Article
  20. A Review of Extracellular Vesicles in COVID-19 Diagnosis, Treatment, and Prevention.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Pradip B DevhareDepartment of Pathology, Saint Louis University, MO, USA.
Ratna B RayDepartment of Pathology, Saint Louis University, MO, USA. Electronic address: rayrb@slu.edu.
Saint Louis University · US

Funding

Innate Immunity and Hepatitis C Virus InfectionR01DK081817 · NIDDK · SAINT LOUIS UNIVERSITY · PI RAY, RATNA B. · 2009 to 2020
$3.3M
Racial Disparity of microRNA in Hepatitis C Virus Mediated HepatocellularcarcinomaR21CA188472 · NCI · SAINT LOUIS UNIVERSITY · PI RAY, RATNA B. · 2015 to 2016
$589k
NCI NIH HHS R21 CA188472NIDDK NIH HHS R01 DK081817
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are membrane derived nanometer-sized vesicles. EVs are released by normal, diseased, and transformed cells in vitro and in vivo, and carry lipids, proteins, mRNAs, non-coding RNAs, and even DNA out of cells. Transferring biological information via EVs to neighboring cells and inter-cellular communication not only maintain physiological functions, but also involve in the pathogenesis of several diseases, including cancer. The aim of this review is to discuss the emerging role of EVs in viral hepatitis, non-alcoholic or alcoholic liver disease and liver cancers. We summarize what is known about exosome biogenesis, and role in liver disease progression, and discuss the potential clinical applications of EVs as predictive biomarkers and therapeutic modalities.

Indexed as

Cell CommunicationDisease SusceptibilityAnimalsBiomarkersCell-Derived MicroparticlesExosomesExtracellular VesiclesHumansLiverLiver DiseasesBiomarkersExosomesExtracellular vesiclesHCCLiverNAFLDNASH

Identifiers

PMID29122679
PMCPMC5856598
OpenAlexW2767674693

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.