Evidence map›Paper›PMID 29122456›Full record

ReviewTrends in immunology2018

Sentinels of the Type 2 Immune Response.

Jakob von Moltke, Marion Pepper

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Resident TScience immunology · 2022
    Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
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  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jakob von MoltkeDepartment of Immunology, University of Washington School of Medicine, 750 Republican Street, Seattle, WA 98109, USA.
Marion PepperDepartment of Immunology, University of Washington School of Medicine, 750 Republican Street, Seattle, WA 98109, USA. Electronic address: mpepper@uw.edu.

Funding

The differentiation and function of CD4+ Th2 cells during allergen-induced asthmaR01AI108626 · NIAID · UNIVERSITY OF WASHINGTON · PI PEPPER, MARION · 2014 to 2018
$2.4M
NIAID NIH HHS R01 AI108626
6 · The paper itself

Abstract

Type 2 immune responses have evolved to sense and respond to large, non-replicating infections or non-microbial noxious compounds in tissues. The development of these responses therefore depends upon highly coordinated and tightly regulated tissue-residing cellular sensors and responders. Multiple exposure to type 2 helper T cell (Th2)-inducing stimuli further enhances both the diversity and potency of the response. This review discusses advances in our understanding of the interacting cellular subsets that comprise both primary and secondary type 2 responses. Current knowledge regarding type 2 immune responses in the lung are initially presented and are then contrasted with what is known about the small intestine. The studies described portray an immune response that depends upon well-organized tissue structures, and suggest their modulation as a therapeutic strategy.

Indexed as

AnimalsCellular MicroenvironmentHumansImmunity, CellularImmunotherapyIntestinesLungTh1 CellsTh2 CellsT-Lymphocyte Subsets

Identifiers

PMID29122456
PMCPMC6181126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.