Evidence map›Paper›PMID 29121956›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2017

Regional differences in prognostic value of cardiac valve plane displacement in systemic light-chain amyloidosis.

Marco M Ochs, Thomas Fritz, Nisha Arenja, Johannes Riffel, Florian Andre, Derliz Mereles, Fabian Aus dem Siepen, Ute Hegenbart, Stefan Schönland, Hugo A Katus and 2 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  5. Article
  6. Review
  7. Article
  8. Journal of Cardiovascular Magnetic Resonance: 2017/2018 in review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019
    Review
  9. Review
  10. Journal of Cardiovascular Magnetic Resonance 2017.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Marco M OchsDepartment of Cardiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany. marco.ochs@med.uni-heidelberg.de.
Thomas FritzDepartment of Cardiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.
Nisha ArenjaDepartment of Cardiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.
Johannes RiffelDepartment of Cardiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.
Florian AndreDepartment of Cardiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.
Derliz MerelesDepartment of Cardiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.
Fabian Aus dem SiepenDepartment of Cardiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.
Ute HegenbartDepartment of Hematooncology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.
Stefan SchönlandDepartment of Hematooncology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.
Hugo A KatusDepartment of Cardiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.
Matthias G W FriedrichDepartment of Cardiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.
Sebastian J BussDepartment of Cardiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany.
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo compare the prognostic value of cardiac valve plane displacement (CVPD) on various locations in cardiac light chain (AL) amyloidosis.

methodsConsecutive patients with biopsy-proven cardiac involvement in AL amyloidosis who had undergone cardiovascular magnetic resonance (CMR) between 2005 and 2014 in our institution, were retrospectively identified and data analyzed. The primary combined endpoint was all-cause mortality or heart transplantation. Systolic CVPD were obtained from standard cine bSSFP in 2-, 3- and 4-chamber views at anterior aortic plane systolic excursion (AAPSE); anterior, anterolateral, inferolateral, inferior, inferoseptal mitral (MAPSE); and lateral tricuspid (TAPSE) annular segments.

resultsWe identified 68 patients (58 ± 10 years; 59% male). Median follow-up period was 1.2 years (IQR, 0.3-4.1). Significant differences in CVPD between patients who reached a primary endpoint (n = 44) and transplant-free survivors were found only for AAPSE (6.1 mm (IQR, 4.6-9.4) vs. 8.8 mm (IQR, 6.9-10.4); p = 0.02) and MAPSE

conclusionIn patients with cardiac involvement in AL amyloidosis, systolic CVPD obtained from standard long axis cine views appear to indicate outcome better, when obtained in the anterior aortic plane (AAPSE) and provide incremental prognostic value to LGE and strain measurements.

Indexed as

Magnetic Resonance ImagingMyocardial ContractionVentricular Function, LeftAgedArea Under CurveBiopsyCardiomyopathiesChi-Square DistributionFemaleGermanyHeart TransplantationHumansImmunoglobulin Light-chain AmyloidosisKaplan-Meier EstimateKarnofsky Performance StatusMaleAAPSEAL amyloidosisAnterior aortic plane systolic excursionCardiac valve plane excursionMAPSERisk assessmentTAPSE

Identifiers

PMID29121956
PMCPMC5680757
OpenAlexW2767414298

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.