Evidence map›Paper›PMID 29121946›Full record

ArticleJournal of translational medicine2017

Improving precision of glomerular filtration rate estimating model by ensemble learning.

Xun Liu, Ningshan Li, Linsheng Lv, Yongmei Fu, Cailian Cheng, Caixia Wang, Yuqiu Ye, Shaomin Li, Tanqi Lou

Open access · goldAbstract readValidation Study
In one paragraph

Article in Journal of translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  3. Comparing methods for glomerular filtration rate estimation.Journal of clinical and translational science · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xun LiuDivision of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China. naturestyle@163.com.ORCID http://orcid.org/0000-0002-2360-1429
Ningshan LiSJTU-YALE Joint Center for Biostatistics, Shanghai JiaoTong University, Shanghai, China.
Linsheng LvOperating Room, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yongmei FuEmergency Department, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Cailian ChengDivision of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
Caixia WangDivision of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
Yuqiu YeDivision of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
Shaomin LiDivision of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
Tanqi LouDivision of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China. lou.tq@163.com.
Sun Yat-sen University · CNShanghai Jiao Tong University · CN

Funding

Guangdong Science and Technology Plan 2011B031800084Guangdong Science and Technology Plan 2013B021800190the China Postdoctoral Science Foundation 201104335the Fundamental Research Funds for the Central Universities 11ykpy38the National Natural Science Foundation of China 81070612the National Natural Science Foundation of China 81370866the National Project of Scientific and Technical Supporting Programs Funded by Ministry of Science and Technology of China 2011BAI10B00
6 · The paper itself

Abstract

backgroundAccurate assessment of kidney function is clinically important, but estimates of glomerular filtration rate (GFR) by regression are imprecise.

methodsWe hypothesized that ensemble learning could improve precision. A total of 1419 participants were enrolled, with 1002 in the development dataset and 417 in the external validation dataset. GFR was independently estimated from age, sex and serum creatinine using an artificial neural network (ANN), support vector machine (SVM), regression, and ensemble learning. GFR was measured by 99mTc-DTPA renal dynamic imaging calibrated with dual plasma sample 99mTc-DTPA GFR.

resultsMean measured GFRs were 70.0 ml/min/1.73 m

conclusionsAn ensemble learning model including three variables, the average ANN, SVM, and regression equation values, was more precise than the new regression model. A more complex ensemble learning strategy may further improve GFR estimates.

Indexed as

Kidney Function TestsMachine LearningNeural Networks, ComputerAdultAgedCohort StudiesData Interpretation, StatisticalFemaleGlomerular Filtration RateHumansMaleMiddle AgedModels, TheoreticalQuality ImprovementRenal Insufficiency, ChronicSensitivity and SpecificityChronic kidney diseaseEnsemble learningGlomerular filtration ratePrecisionPrediction

Identifiers

PMID29121946
PMCPMC5679185
OpenAlexW2768029705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.