ArticleBMC veterinary research2017
Case definition terminology for paratuberculosis (Johne's disease).
Article in BMC veterinary research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of bovine paratuberculosis in Chinese cattle populations: a meta-analysis.Frontiers in cellular and infection microbiology · 2024Pooled it
- A Longitudinal Study ofAnimals : an open access journal from MDPI · 2026Article
- Candidate Faecal microRNAs as Non-Invasive Biomarkers for Bovine Paratuberculosis inInternational journal of molecular sciences · 2026Article
- Systematic evaluation and optimization of TaqMan qPCR assays targeting FJournal of clinical microbiology · 2026Article
- Age-adjusted ELISA cutoffs for Johne's disease in young adult dairy cattle using Bayesian nonparametric models.Frontiers in veterinary science · 2026Article
- Specificity Evaluation of a Polyprotein-Based ELISA Designed for the Detection of Paratuberculosis in Multiple Species.Veterinary medicine international · 2026Article
- MicroRNA-mediated regulatory mechanisms in cow's ileum and ileum lymph node in response to Mycobacterium avium subspecies paratuberculosis infection.Scientific reports · 2025Article
- Cytokeratin expression and distribution pattern of epithelioid macrophages in animals with different pathological forms of bovine paratuberculosis: potential role in resilience to PTB.Frontiers in veterinary science · 2025Article
- Caprine Paratuberculosis Seroprevalence and Immune Response to Anti-Veterinary sciences · 2024Article
- Retrospective Single Nucleotide Polymorphism Analysis of Host Resistance and Susceptibility to Ovine Johne's Disease Using Restored FFPE DNA.International journal of molecular sciences · 2024Article
- An ELISA Using Synthetic Mycolic Acid-Based Antigens with DIVA Potential for Diagnosing Johne's Disease in Cattle.Animals : an open access journal from MDPI · 2024Article
- Detection of caprine paratuberculosis (Johne's disease) in pre- and post-vaccinated herds: morphological diagnosis, lesion grading, and bacterial identification.Frontiers in veterinary science · 2024Article
- Evaluation of Single Nucleotide Polymorphisms (SNPs) Associated with Genetic Resistance to Bovine Paratuberculosis inAnimals : an open access journal from MDPI · 2023Article
- Local assessment of the immunohistochemical expression of Foxp3BMC veterinary research · 2022Article
- First identification ofVeterinary world · 2022Article
- Correlates of vaccine protection againstFrontiers in veterinary science · 2022Article
- Paratuberculosis: The Hidden Killer of Small Ruminants.Animals : an open access journal from MDPI · 2021Review
- The Paratuberculosis Paradigm Examined: A Review of Host Genetic Resistance and Innate Immune Fitness inFrontiers in veterinary science · 2021Review
- Seroprevalence ofVeterinary sciences · 2020Article
- Ovine Paratuberculosis Control in Australia Revisited.Animals : an open access journal from MDPI · 2020Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Paratuberculosis (Johne's disease) is an economically significant condition caused by Mycobacterium avium subsp. paratuberculosis. However, difficulties in diagnosis and classification of individual animals with the condition have hampered research and impeded efforts to halt its progressive spread in the global livestock industry. Descriptive terms applied to individual animals and herds such as exposed, infected, diseased, clinical, sub-clinical, infectious and resistant need to be defined so that they can be incorporated consistently into well-understood and reproducible case definitions. These allow for consistent classification of individuals in a population for the purposes of analysis based on accurate counts. The outputs might include the incidence of cases, frequency distributions of the number of cases by age class or more sophisticated analyses involving statistical comparisons of immune responses in vaccine development studies, or gene frequencies or expression data from cases and controls in genomic investigations. It is necessary to have agreed definitions in order to be able to make valid comparisons and meta-analyses of experiments conducted over time by a given researcher, in different laboratories, by different researchers, and in different countries. In this paper, terms are applied systematically in an hierarchical flow chart to enable classification of individual animals. We propose descriptive terms for different stages in the pathogenesis of paratuberculosis to enable their use in different types of studies and to enable an independent assessment of the extent to which accepted definitions for stages of disease have been applied consistently in any given study. This will assist in the general interpretation of data between studies, and will facilitate future meta-analyses.
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