ArticleCardiovascular diabetology2017
Impact of overweight on left ventricular function in type 2 diabetes mellitus.
Article in Cardiovascular diabetology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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27 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Subclinical systolic dysfunction detected by 2D speckle tracking echocardiography in adults with diabetes mellitus: systematic review and meta-analysis of 6668 individuals with diabetes mellitus and 7218 controls.The international journal of cardiovascular imaging · 2023Pooled it
- Comprehensive CMR evaluation including 4D flow-derived E/A vorticity ratio in overweight adults with and without type 2 diabetes mellitus.Cardiovascular diabetology · 2025Trial
- Strain imaging in heart failure: from early detection to prognostic assessment.ESC heart failure · 2026Review
- Myocardial interstitial fibrosis and subclinical left ventricular systolic dysfunction in type 2 diabetes mellitus patients with obesity: a 3.0 T MRI study.Cardiovascular diabetology · 2025Article
- Evolving role of echocardiography across the heart failure spectrum: from prevention to advanced management.Heart failure reviews · 2025Review
- Effect of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) on Left Ventricular Mechanics in Patients Without Overt Cardiac Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Three-dimensional echocardiography and strain cardiac imaging in patients with prediabetes and type 2 diabetes mellitus.Quantitative imaging in medicine and surgery · 2023Article
- Fat Mass is Associated with Subclinical Left Ventricular Systolic Dysfunction in Patients with Type 2 Diabetes Mellitus Without Established Cardiovascular Diseases.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2023Article
- Article
- Modified Haller index validation and correlation with left ventricular strain in a cohort of subjects with obesity and without overt heart disease.Internal and emergency medicine · 2022Article
- Liver stiffness measurement identifies subclinical myocardial dysfunction in non-advanced non-alcoholic fatty liver disease patients without overt heart disease.Internal and emergency medicine · 2022Article
- Association of body mass index with left ventricular diastolic dysfunction among ambulatory individuals with diabetes mellitus in rural Uganda: a cross-sectional study.BMC cardiovascular disorders · 2022Article
- Impact of cardiovascular risk factors on myocardial work-insights from the STAAB cohort study.Journal of human hypertension · 2022Article
- Article
- Relationship between arterial stiffness and chronic kidney disease in patients with primary hypertension.Journal of human hypertension · 2020Article
- The incidence of diabetes among the non-diabetic residents in Kawauchi village, Fukushima, who experienced evacuation after the 2011 Fukushima Daiichi nuclear power plant disaster.Environmental health and preventive medicine · 2020Article
- Article
- Making sense of subclinical cardiac alterations in patients with diabetes.Bosnian journal of basic medical sciences · 2019Article
- Phenotyping diabetic cardiomyopathy in Europeans and South Asians.Cardiovascular diabetology · 2019Article
- Impact of acute hyperglycemia on layer-specific left ventricular strain in asymptomatic diabetic patients: an analysis based on two-dimensional speckle tracking echocardiography.Cardiovascular diabetology · 2019Article
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoexistence of left ventricular (LV) longitudinal myocardial systolic dysfunction with LV diastolic dysfunction could lead to heart failure with preserved ejection fraction (HFpEF). Diabetes mellitus (DM) is known as a significant factor associated with HFpEF. Although the mechanisms of DM-related LV myocardial injury are complex, it has been postulated that overweight contributes to the development of LV myocardial injury in type 2 diabetes mellitus (T2DM) patients. However, the precise impact of overweight on LV longitudinal myocardial systolic function in T2DM patients remains unclear.
methodsWe studied 145 asymptomatic T2DM patients with preserved LV ejection fraction (LVEF) without coronary artery disease. LV longitudinal myocardial systolic function was assessed by global longitudinal strain (GLS), which was defined as the average peak strain of 18-segments obtained from standard apical views. Overweight was defined as body mass index (BMI) ≥ 25 kg/m
resultsGLS of overweight T2DM patients was significantly lower than that of non-overweight patients (17.9 ± 2.4% vs. 18.9 ± 2.6%, p < 0.05), whereas GLS of both overweight and non-overweight controls was similar (19.8 ± 1.3% vs. 20.4 ± 2.1%, p = 0.38). Furthermore, multiple regression analysis revealed that for T2DM patients, BMI was the independent determinant parameters for GLS as well as LV mass index.
conclusionsOverweight has a greater effect on LV longitudinal myocardial systolic function in T2DM patients than on that in non-DM healthy subjects. Our finding further suggests that the strict control of overweight in T2DM patients may be associated with prevention of the development of HFpEF.
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