Evidence map›Paper›PMID 29121906›Full record

ArticleBMC musculoskeletal disorders2017

Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear.

Ana P Valencia, Shama R Iyer, Espen E Spangenburg, Mohit N Gilotra, Richard M Lovering

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Rotator cuff tears.Nature reviews. Disease primers · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Biotoxins in muscle regeneration research.Journal of muscle research and cell motility · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ana P ValenciaDepartment of Orthopaedics, University of Maryland School of Medicine, AHB, Rm 540, 100 Penn St., Baltimore, MD, 21201, USA.
Shama R IyerDepartment of Orthopaedics, University of Maryland School of Medicine, AHB, Rm 540, 100 Penn St., Baltimore, MD, 21201, USA.
Espen E SpangenburgDepartment of Physiology, East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, USA.
Mohit N GilotraDepartment of Orthopaedics, University of Maryland School of Medicine, AHB, Rm 540, 100 Penn St., Baltimore, MD, 21201, USA.
Richard M LoveringDepartment of Orthopaedics, University of Maryland School of Medicine, AHB, Rm 540, 100 Penn St., Baltimore, MD, 21201, USA. rlovering@som.umaryland.edu.
University of Maryland, Baltimore · USEast Carolina University · US

Funding

Interdisciplinary Training Program Muscle BiologyT32AR007592 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI Aikaterini Kontrogianni-Konstantopoulos · 1996 to 2026
$11.7M
Mechanisms of Force Loss in Injured and Dystrophic Skeletal MuscleR01AR059179 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LOVERING, RICHARD M · 2010 to 2014
$1.4M
E-Technology for Chinese Dementia CaregiversR44AG026815 · NIA · ENVIRONMENT AND HEALTH GROUP, INC. · PI CHEN, HONGTU · 2009 to 2010
$1.1M
Targeting of cells to musculoskeletal injury via superparamagenetic nanoparticlesR21AR067872 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI LOVERING, RICHARD M · 2016 to 2017
$373k
E-Technology for Chinese Dementia CaregiversR43AG026815 · NIA · ENVIRONMENT AND HEALTH GROUP, INC. · PI CHEN, HONGTU · 2006 to 2006
$117k
National Heart, Lung, and Blood Institute T32AG00026815S1National Institute of Arthritis and Musculoskeletal and Skin Diseases AR07592-20National Institute of Arthritis and Musculoskeletal and Skin Diseases R01-AR059179National Institute of Arthritis and Musculoskeletal and Skin Diseases R21-AR067872NIAMS NIH HHS R01 AR059179NIAMS NIH HHS R21 AR067872NIAMS NIH HHS T32 AR007592NIA NIH HHS R43 AG026815NIA NIH HHS R44 AG026815
6 · The paper itself

Abstract

backgroundRotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to contractile function. This study assessed supraspinatus force and susceptibility to injury in the rat model of RTC tear, and compared these functional changes to histopathology of the muscle.

methodsUnilateral RTC tears were induced in male rats via tenotomy of the supraspinatus and infraspinatus. Maximal tetanic force and susceptibility to injury of the supraspinatus muscle were measured in vivo at day 2 and day 15 after tenotomy. Supraspinatus muscles were weighed and harvested for histologic analysis of the neuromuscular junction (NMJ), intramuscular lipid, and collagen.

resultsTenotomy resulted in eventual atrophy and weakness. Despite no loss in muscle mass at day 2 there was a 30% reduction in contractile force, and a decrease in NMJ continuity and size. Reduced force persisted at day 15, a time point when muscle atrophy was evident but NMJ morphology was restored. At day 15, torn muscles had decreased collagen-packing density and were also more susceptible to contraction-induced injury.

conclusionMuscle size and histopathology are not direct indicators of overall RTC contractile health. Changes in NMJ morphology and collagen organization were associated with changes in contractile function and thus may play a role in response to injury. Although our findings are limited to the acute phase after a RTC tear, the most salient finding is that RTC tenotomy results in increased susceptibility to injury of the supraspinatus.

Indexed as

Muscle ContractionAdiposityAnimalsBiomarkersFibrosisMaleMuscular AtrophyNeuromuscular JunctionRandom AllocationRats, Sprague-DawleyRotator CuffRotator Cuff InjuriesBiomarkersCollagen organizationContractilityEccentric injuryMuscle forceNeuromuscular junctionRat

Identifiers

PMID29121906
PMCPMC5679320
OpenAlexW2767721977

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.