Evidence map›Paper›PMID 29121487›Full record

ArticleTranslational research : the journal of laboratory and clinical medicine2018

Risk of cardiac events in Long QT syndrome patients when taking antiseizure medications.

David S Auerbach, Yitschak Biton, Bronislava Polonsky, Scott McNitt, Robert A Gross, Robert T Dirksen, Arthur J Moss

Open access · greenAbstract read
In one paragraph

Article in Translational research : the journal of laboratory and clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Epilepsy and long-term risk of arrhythmias.European heart journal · 2023
    Article
  9. Review
  10. The ERG1 KFrontiers in molecular neuroscience · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

David S AuerbachDepartment of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Pharmacology & Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY. Electronic address: david_auerbach@urmc.rochester.edu.
Yitschak BitonDepartment of Medicine, Heart Research Follow up Program, University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass.
Bronislava PolonskyDepartment of Medicine, Heart Research Follow up Program, University of Rochester School of Medicine and Dentistry, Rochester, NY.
Scott McNittDepartment of Medicine, Heart Research Follow up Program, University of Rochester School of Medicine and Dentistry, Rochester, NY.
Robert A GrossDepartment of Pharmacology & Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY.
Robert T DirksenDepartment of Pharmacology & Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY.
Arthur J MossDepartment of Medicine, Heart Research Follow up Program, University of Rochester School of Medicine and Dentistry, Rochester, NY.
University of Rochester · USHarvard University · US

Funding

Training and Educational CoreU54NS048843 · NINDS · UNIVERSITY OF ROCHESTER · PI MOXLEY, RICHARD T · 2003 to 2017
$21.9M
LONG QT SYNDROME--POPULATION, GENETIC, &CARDIAC STUDIESR01HL033843 · NHLBI · UNIVERSITY OF ROCHESTER · PI MOSS, ARTHUR J. · 1985 to 2011
$5.9M
Institutional Career Development CoreKL2TR001999 · NCATS · UNIVERSITY OF ROCHESTER · PI XIAO, JIN · 2016 to 2024
$5.2M
Clinical and Basic Science Studies in Long QT Syndrome Type 3R01HL123483 · NHLBI · UNIVERSITY OF ROCHESTER · PI KASS, ROBERT S, ZAREBA, WOJCIECH · 2014 to 2018
$3.7M
The Administrative Core of the Center of SUDEP ResearchU01NS090405 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LHATOO, SAMDEN, NOEBELS, JEFFREY · 2014 to 2018
$3.2M
The University of Rochester Clinical and Translational Science InstituteKL2TR000095 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$1.7M
LONG QT SYNDROME--GENETIC STUDIESR01HL051618 · NHLBI · UNIVERSITY OF ROCHESTER · PI MOSS, ARTHUR J. · 1993 to 2002
$1.2M
NCATS NIH HHS KL2 TR000095NCATS NIH HHS KL2 TR001999NHLBI NIH HHS R01 HL033843NHLBI NIH HHS R01 HL051618NHLBI NIH HHS R01 HL123483NINDS NIH HHS U01 NS090405NINDS NIH HHS U54 NS048843
6 · The paper itself

Abstract

Many antiseizure medications (ASMs) affect ion channel function. We investigated whether ASMs alter the risk of cardiac events in patients with corrected QT (QT

Indexed as

Adrenergic beta-AntagonistsAdultAnticonvulsantsCohort StudiesElectrocardiographyFemaleGABA AgentsHeart DiseasesHumansLong QT SyndromeMaleRisk FactorsVoltage-Gated Sodium Channel BlockersAdrenergic beta-AntagonistsAnticonvulsantsGABA AgentsVoltage-Gated Sodium Channel Blockers

Identifiers

PMID29121487
PMCPMC5733703
OpenAlexW2766058543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.