ArticleInternational journal of epidemiology2017
Community characteristics and regional variations in sepsis.
Article in International journal of epidemiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Monocyte Distribution Width for Sepsis Diagnosis in the Emergency Department and Intensive Care Unit: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Health Disparities and Sepsis: a Systematic Review and Meta-Analysis on the Influence of Race on Sepsis-Related Mortality.Journal of racial and ethnic health disparities · 2019Pooled it
- Association Between Community-Level Social Determinants of Health and Sepsis Incidence and Mortality: A Scoping Review.Critical care explorations · 2026Article
- Machine learning to assess correlated sociodemographic and socioeconomic community-level data and association with sepsis incidence.Journal of critical care · 2026Article
- A Cohort Study on Clinical Features and Microbiological Profile in Neonatal Sepsis in Southwest of Iran.Health science reports · 2025Article
- Geographic Clusters in Sepsis Hospital Mortality and the Role of Targeted Regionalization.Critical care medicine · 2025Article
- Cost-effectiveness of Procalcitonin (PCT) guidance for antibiotics management of adult sepsis patients in the Egyptian context.BMC health services research · 2024Article
- National incidence and mortality of hospitalized sepsis in China.Critical care (London, England) · 2023Article
- Is patients' rurality associated with in-hospital sepsis death in US hospitals?Frontiers in public health · 2023Article
- Proteomic changes associated with racial background and sepsis survival outcomes.Molecular omics · 2022Article
- Prescribing of Pressor Agents in Septic Shock: A Survey of Critical Care Pharmacists.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2019Article
- Epidemiology of Sepsis-3 in a sub-district of Beijing: secondary analysis of a population-based database.Chinese medical journal · 2019Article
- The effect of community socioeconomic status on sepsis-attributable mortality.Journal of critical care · 2018Article
- Acetylation-Dependent Regulation of Notch Signaling in Macrophages by SIRT1 Affects Sepsis Development.Frontiers in immunology · 2018Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Background: Sepsis may contribute to more than 200 000 annual deaths in the USA. Little is known about the regional patterns of sepsis mortality and the community characteristics that explain this relationship. We aimed to determine the influence of community characteristics upon regional variations in sepsis incidence and case fatality. Methods: We performed a retrospective analysis of data from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Using US sepsis mortality data, we used two strategies for defining geographic regions: (i) Sepsis 'Belt' vs Non-Belt and (ii) Sepsis 'Cluster' vs Non-Cluster. We determined sepsis incidence and case fatality among REGARDS participants in each region, adjusting for participant characteristics. We examined the mediating effect of community characteristics upon regional variations in sepsis incidence and case fatality. Results: Among 29 680 participants, 16 493 (55.6%) resided in the Sepsis Belt and 2958 (10.0%) resided in a Sepsis Cluster. Sepsis incidence was higher for Sepsis Belt than Non-Belt participants [adjusted hazard ratio (HR) = 1.14; 95% confidence interval (CI) = 1.02-1.24] and higher for Sepsis Cluster than Non-Cluster participants (adjusted HR = 1.18; 95% CI = 1.01-1.39). Sepsis case fatality was similar between Sepsis Belt and Non-Belt participants, as well as between Cluster and Non-Cluster participants. Community poverty mediated the regional differences in sepsis incidence. Conclusions: Regional variations in sepsis incidence may be partly explained by community poverty. Other community characteristics do not explain regional variations in sepsis incidence or case fatality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.