ArticleBritish journal of anaesthesia2017
Disruption of cortical network activity by the general anaesthetic isoflurane.
Article in British journal of anaesthesia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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24 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Effects of EEG-guided anesthetic depth monitoring on delirium incidence across different age groups: a systematic review and meta-analysis.BMC anesthesiology · 2026Pooled it
- Low-intensity transcranial focused ultrasound engages parvalbumin-positive GABAergic interneurons in a humanized mouse model of chronic pain: from electrophysiology to cellular investigation.Journal of neural engineering · 2026Article
- Neuronal Dynamics During Isoflurane Induction inbioRxiv : the preprint server for biology · 2026Article
- The Administration of Ketamine Is Associated with Dose-Dependent Stabilization of Cortical Dynamics in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Myelin modulates the process of isoflurane anesthesia through the regulation of neural activity.CNS neuroscience & therapeutics · 2024Article
- Characterization and closed-loop control of infrared thalamocortical stimulation produces spatially constrained single-unit responses.PNAS nexus · 2024Article
- Brain state identification and neuromodulation to promote recovery of consciousness.Brain communications · 2024Review
- Holistic bursting cells store long-term memory in auditory cortex.Nature communications · 2023Article
- Amplitude- and frequency-dependent activation of layer II/III neurons by intracortical microstimulation.iScience · 2023Article
- Spatially specific, closed-loop infrared thalamocortical deep brain stimulation.bioRxiv : the preprint server for biology · 2023Article
- Unraveling the mechanisms of deep-brain stimulation of the internal capsule in a mouse model.Nature communications · 2023Article
- Awake perception is associated with dedicated neuronal assemblies in the cerebral cortex.Nature neuroscience · 2022Article
- Effects of General Anesthetics on Synaptic Transmission and Plasticity.Current neuropharmacology · 2022Review
- Molecular Diversity of Anesthetic Actions Is Evident in Electroencephalogram Effects in Humans and Animals.International journal of molecular sciences · 2021Review
- Propofol Affects Cortico-Hippocampal Interactions via β3 Subunit-Containing GABAInternational journal of molecular sciences · 2020Article
- Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics.Journal of visualized experiments : JoVE · 2020Article
- Article
- The (Un)Conscious Mouse as a Model for Human Brain Functions: Key Principles of Anesthesia and Their Impact on Translational Neuroimaging.Frontiers in systems neuroscience · 2020Review
- Selective effects of isoflurane on cortico-cortical feedback afferent responses in murine non-primary neocortex.British journal of anaesthesia · 2019Article
- Understanding the Effects of General Anesthetics on Cortical Network Activity Using Ex Vivo Preparations.Anesthesiology · 2019Review
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5 authors at 2 institutions in 3 countries.
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Abstract
backgroundActions of general anaesthetics on activity in the cortico-thalamic network likely contribute to loss of consciousness and disconnection from the environment. Previously, we showed that the general anaesthetic isoflurane preferentially suppresses cortically evoked synaptic responses compared with thalamically evoked synaptic responses, but how this differential sensitivity translates into changes in network activity is unclear.
methodsWe investigated isoflurane disruption of spontaneous and stimulus-induced cortical network activity using multichannel recordings in murine auditory thalamo-cortical brain slices.
resultsUnder control conditions, afferent stimulation elicited short latency, presumably monosynaptically driven, spiking responses, as well as long latency network bursts that propagated horizontally through the cortex. Isoflurane (0.05-0.6 mM) suppressed spiking activity overall, but had a far greater effect on network bursts than on early spiking responses. At isoflurane concentrations >0.3 mM, network bursts were almost entirely blocked, even with increased stimulation intensity and in response to paired (thalamo-cortical + cortical layer 1) stimulation, while early spiking responses were <50% blocked. Isoflurane increased the threshold for eliciting bursts, decreased their propagation speed and prevented layer 1 afferents from facilitating burst induction by thalamo-cortical afferents.
conclusionsDisruption of horizontal activity spread and of layer 1 facilitation of thalamo-cortical responses likely contribute to the mechanism by which suppression of cortical feedback connections disrupts sensory awareness under anaesthesia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.