ArticleNeuro-oncology2018
Exercise ameliorates neurocognitive impairments in a translational model of pediatric radiotherapy.
Article in Neuro-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The Potential of Physical Exercise to Mitigate Radiation Damage-A Systematic Review.Frontiers in medicine · 2021Pooled it
- Acute effects of different physical activity on executive function and regulation role of beta oscillation in sedentary youth frontal region.Scientific reports · 2024Article
- Review
- Adulthood effects of developmental exercise in rats.Developmental psychobiology · 2024Article
- The association of environmental factors with neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia (ALL).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Neurotoxicity from Old and New Radiation Treatments for Brain Tumors.International journal of molecular sciences · 2023Review
- Processing speed dysfunction is associated with functional corticostriatal circuit alterations in childhood epilepsy with centrotemporal spikes: a PET and fMRI study.European journal of nuclear medicine and molecular imaging · 2022Article
- Changes in Brain Functional and Effective Connectivity After Treatment for Breast Cancer and Implications for Intervention Targets.Brain connectivity · 2022Article
- Cognitive and Imaging Differences After Proton and Photon Whole Brain Irradiation in a Preclinical Model.International journal of radiation oncology, biology, physics · 2022Article
- Brain Imaging in Pediatric Cancer Survivors: Correlates of Cognitive Impairment.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice.Brain plasticity (Amsterdam, Netherlands) · 2020Article
- Functional connectome biotypes of chemotherapy-related cognitive impairment.Journal of cancer survivorship : research and practice · 2020Article
- Predicting Patient Reported Outcomes of Cognitive Function Using Connectome-Based Predictive Modeling in Breast Cancer.Brain topography · 2020Article
- Shaping the adult brain with exercise during development: Emerging evidence and knowledge gaps.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019Review
- Particle Radiation Induced Neurotoxicity in the Central Nervous System.International journal of particle therapy · 2018Review
- Olfactory Memory Impairment Differs by Sex in a Rodent Model of Pediatric Radiotherapy.Frontiers in behavioral neuroscience · 2018Article
- A comprehensive preclinical assessment of late-term imaging markers of radiation-induced brain injury.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: While cranial radiation therapy (CRT) is an effective treatment, healthy areas surrounding irradiation sites are negatively affected. Frontal lobe functions involving attention, processing speed, and inhibition control are impaired. These deficits appear months to years after CRT and impair quality of life. Exercise has been shown to rejuvenate the brain and aid in recovery post-injury through its effects on neurogenesis and cognition. Methods: We developed a juvenile rodent CRT model that reproduces neurocognitive deficits. Next, we utilized the model to test whether exercise ameliorates these deficits. Fischer rats (31 days old) were irradiated with a fractionated dose of 4 Gy × 5 days, trained and tested at 6, 9, and 12 months post-CRT using 5-choice serial reaction time task. After testing, fixed rat brains were imaged using diffusion tensor imaging and immunohistochemistry. Results: CRT caused early and lasting impairments in task acquisition, accuracy, and latency to correct response, as well as causing stunting of growth and changes in brain volume and diffusion. Exercising after irradiation improved acquisition, behavioral control, and processing speed, mitigated the stunting of brain size, and increased brain fiber numbers compared with sedentary CRT values. Further, exercise partially restored global connectome organization, including assortativity and characteristic path length, and while it did not improve the specific regional connections that were lowered by CRT, it appeared to remodel these connections by increasing connectivity between alternate regional pairs. Conclusions: Our data strongly suggest that exercise may be useful in combination with interventions aimed at improving cognitive outcome following pediatric CRT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.