ArticlePloS one2017
Nature is the best source of anticancer drugs: Indexing natural products for their anticancer bioactivity.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
128 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Marine Natural Products as Potent Anticancer Agents (2020-2024): Structural Diversity, SARs and Target Prediction.Marine drugs · 2026Pooled it
- Cytotoxic and Apoptotic Effects of Compounds Isolated from Atalantia monophylla Peels on Human Cancer Cell Lines.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Preclinical evaluation of Ayurveda and Siddha Herbo-mineral formulations in cancer: A scoping review protocol.PloS one · 2026Article
- The Role of Coumarins in Drug Discovery: Pharmacological Insights and Structural Innovations.Current topics in medicinal chemistry · 2026Review
- Exploring chemical composition, anti-acetylcholinesterase, and anticancer activities ofPharmaceutical biology · 2025Article
- Screening the Active Phytochemicals FromCancer innovation · 2025Review
- Effect of Precipitated Extracellular Marennine on Angiogenesis and Tumour Cell Proliferation.Marine drugs · 2025Article
- Marine life as a source of anti-prostate cancer agents: an updated overview (2003-2023).Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Anticancer Effects of Withanolides: In Silico Prediction of Pharmacological Properties.Molecules (Basel, Switzerland) · 2025Article
- Advances in nano drug delivery systems for enhanced efficacy of emodin in cancer therapy.International journal of pharmaceutics: X · 2025Review
- Cancer chemoprevention: signaling pathways and strategic approaches.Signal transduction and targeted therapy · 2025Review
- Synergistic strength: unleashing exercise and polyphenols against breast cancer.Cancer cell international · 2025Review
- Phytochemical Characterization and Anticancer Activity ofInternational journal of molecular sciences · 2025Article
- Article
- Antioxidant and Anti-Proliferative Effects ofLife (Basel, Switzerland) · 2024Article
- Pharmacological effects of bioactive agents in earthworm extract: A comprehensive review.Animal models and experimental medicine · 2024Review
- Discovery of a 6-Aminobenzo[ACS pharmacology & translational science · 2024Article
- From Sequence to Solution: Intelligent Learning Engine Optimization in Drug Discovery and Protein Analysis.Biotech (Basel (Switzerland)) · 2024Article
- Discovery of Potent IsoquinolinequinoneJournal of medicinal chemistry · 2024Article
- Cytotoxic Activity ofMolecules (Basel, Switzerland) · 2024Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is considered one of the primary diseases that cause morbidity and mortality in millions of people worldwide and due to its prevalence, there is undoubtedly an unmet need to discover novel anticancer drugs. However, the traditional process of drug discovery and development is lengthy and expensive, so the application of in silico techniques and optimization algorithms in drug discovery projects can provide a solution, saving time and costs. A set of 617 approved anticancer drugs, constituting the active domain, and a set of 2,892 natural products, constituting the inactive domain, were employed to build predictive models and to index natural products for their anticancer bioactivity. Using the iterative stochastic elimination optimization technique, we obtained a highly discriminative and robust model, with an area under the curve of 0.95. Twelve natural products that scored highly as potential anticancer drug candidates are disclosed. Searching the scientific literature revealed that few of those molecules (Neoechinulin, Colchicine, and Piperolactam) have already been experimentally screened for their anticancer activity and found active. The other phytochemicals await evaluation for their anticancerous activity in wet lab.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.