ArticlePloS one2017
Fetal overgrowth in women with type 1 and type 2 diabetes mellitus.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Associations of modifiable preconception, pregnancy and postpartum factors with health outcomes for women with type 2 diabetes and their children: A systematic review and meta-analysis of observational studies.Diabetic medicine : a journal of the British Diabetic Association · 2026Pooled it
- Effect of Prenatal Care on Perinatal Outcomes of Pregnant Women with Diabetes Mellitus: A Systematic Review.The Yale journal of biology and medicine · 2024Pooled it
- Supplementation of EPA and DHA in pregnant women with type 1 diabetes mellitus.Annals of medicine · 2021Trial
- Continuous Glucose Monitoring Time-in-Range and HbADiabetes technology & therapeutics · 2021Trial
- Glycemic control and fetal growth of women with diabetes mellitus and subsequent hypertensive disorders of pregnancy.PloS one · 2020Trial
- Body Weight-Related Parameters in Pregnancies Complicated by Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis with Maternal and Perinatal Outcome Mapping.Journal of clinical medicine · 2026Review
- Genetic Evaluation and Pregnancy Outcomes in Foetuses With Overgrowth at a Tertiary Referral Center.Journal of cellular and molecular medicine · 2026Article
- Patterns of weight gain during the first half of pregnancy and risk of large newborns in women with insulin-dependent diabetes mellitus.Pregnancy (Hoboken, N.J.) · 2026Article
- Well-controlled type 2 diabetes mellitus in pregnancy showed smaller fetal biometry and neonatal birth weight compared to other glycemic disorders and healthy pregnancies: a comparative cohort study.Journal of diabetes and metabolic disorders · 2025Article
- Timing and Variability of Maternal Hyperglycemia in Insulin-Dependent Diabetes, Long-Term Effects on Offspring Obesity-The TEAM Study.Pregnancy (Hoboken, N.J.) · 2025Article
- Impact of Gestational Diabetes on Neonatal Birth Weight and Maternal Postpartum Metabolic Changes.Cureus · 2025Article
- Differential Effects of First and Third Trimester HbA1c Levels on Neonatal Weight and Placental Mediation in Type 1 Diabetes.Frontiers in endocrinology · 2025Observational
- Pregnancy outcomes in type 2 versus type 1 diabetes: systematic review with meta-analyses.Endocrine connections · 2024Article
- Prematurity and congenital malformations differ according to the type of pregestational diabetes.BMC pregnancy and childbirth · 2024Observational
- Clinical factors associated with birth weight of infants born to pregnant women with diabetes.Diabetology international · 2024Article
- Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles.Nutrients · 2024Article
- Article
- Anti-inflammatory diets reduce the risk of excessive gestational weight gain in urban South Africans from the Soweto First 1000-Day Study (S1000).European journal of nutrition · 2022Article
- Glycemic Variability in Type 1 Diabetes Mellitus Pregnancies-Novel Parameters in Predicting Large-for-Gestational-Age Neonates: A Prospective Cohort Study.Biomedicines · 2022Article
- Altered protein O-GlcNAcylation in placentas from mothers with diabetes causes aberrant endocytosis in placental trophoblast cells.Scientific reports · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesDespite improved glycemic control, the rate of large-for-gestational-age (LGA) infants remains high in pregnancies complicated by diabetes mellitus type 1 (T1DM) and type 2 (T2DM). Poor glycemic control, obesity, and excessive gestational weight gain are the main risk factors. The aim of this study was to determine the relative contribution of these risk factors for LGA in women with T1DM and T2DM, after controlling for important confounders such as age, smoking, and parity.
methodsIn this retrospective chart review study, we analyzed the medical files of pregnant women with T1DM and T2DM who attended the antenatal care program at Skåne University Hospital during the years 2006 to 2016. HbA1c was used as a measure of glycemic control. Maternal weight in early pregnancy and at term was registered. LGA was defined as birth weight > 2 standard deviations of the mean. Univariable and multivariable logistic regression analysis was used to calculate odds ratios (OR's) and 95% confidence intervals (CIs) for LGA.
resultsOver the 11-year period, we identified 308 singleton pregnancies in 221 women with T1DM and in 87 women with T2DM. The rate of LGA was 50% in women with T1DM and 23% in women with T2DM. The multivariable regression model identified gestational weight gain and second-trimester HbA1c as risk factors for LGA in T1DM pregnancies (OR = 1.107, 95% CI: 1.044-1.17, and OR = 1.047, 95% CI: 1.015-1.080, respectively) and gestational weight gain as a risk factor in T2DM pregnancies (OR = 1.175, 95% CI: 1.048-1.318), independent of body mass index.
conclusionsGestational weight gain was associated with LGA in women with T1DM and T2DM, independent of maternal body mass index. The findings suggest that monitoring and regulation of gestational weight gain is important in the clinical care of these women, to minimize the risk of fetal overgrowth.
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