ArticlePloS one2017
Improved segmented modified Look-Locker inversion recovery T1 mapping sequence in mice.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Left ventricle strain and T1 mapping evaluation in a mouse model with myocardial infarction.Scientific reports · 2025Article
- Cardiovascular magnetic resonance imaging for sequential assessment of cardiac fibrosis in mice: technical advancements and reverse translation.American journal of physiology. Heart and circulatory physiology · 2024Review
- Biomedical Imaging in Experimental Models of Cardiovascular Disease.Circulation research · 2022Review
- Radial MP2RAGE sequence for rapid 3D TEuropean radiology · 2019Article
- Simultaneous Assessment of Cardiac Inflammation and Extracellular Matrix Remodeling after Myocardial Infarction.Circulation. Cardiovascular imaging · 2018Article
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
objectTo develop and evaluate a 2D modified Look-Locker (MOLLI) for high-resolution T1 mapping in mice using a 3T MRI scanner. MATERIALS AND
methodsTo allow high-resolution T1 mapping in mice at high heart rates a multi-shot ECG-triggered 2D MOLLI sequence was developed. In the proposed T1 mapping sequence the optimal number of sampling points and pause cardiac cycles following an initial adiabatic inversion pulse was investigated in a phantom. Seven native control and eight mice, 3 days post myocardial infarction (MI) after administration of gadolinium were scanned. Two experienced readers graded the visual T1 map quality.
resultsIn T1 phantoms, there were no significant differences (<0.4% error) between 12, 15 and 20 pause cardiac cycles (p = 0.1, 0.2 and 0.6 respectively) for 8 acquisition cardiac cycles for 600bpm in comparison to the conventional inversion recovery spin echo T1 mapping sequence for short T1's (<600 ms). Subsequently, all in-vivo scans were performed with 8 data acquisitions and 12 pause cardiac cycles to minimize scan time. The mean native T1 value of myocardium in control animal was 820.5±52 ms. The post-contrast T1 measured 3 days after MI in scar was 264±59 ms and in healthy myocardium was 512±62 ms. The Bland-Altman analysis revealed mean difference of only -1.06% of infarct size percentage between T1 maps and LGE.
conclusionsA multi-shot 2D MOLLI sequence has been presented that allows reliable measurement of high spatial resolution T1 maps in mice for heart rates up to 600bpm.
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