Evidence map›Paper›PMID 29120692›Full record

ReviewAnnual review of physiology2018

Epithelial Na

Thomas R Kleyman, Ossama B Kashlan, Rebecca P Hughey

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 95 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Kidney kallikrein-1 contributes to cleavage of γ-ENaC in vivo.American journal of physiology. Renal physiology · 2026
    Article
  5. Kidney kallikrein-1 contributes to cleavage of gamma-ENaCbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. SECS, drugs, and Rac1&Rho: regulation of EnNaC in vascular endothelial cells.Pflugers Archiv : European journal of physiology · 2025
    Article
  9. Article
  10. Review
  11. Epithelial Na+ Channels, Immune Cells, and Salt.Annual review of physiology · 2025
    Review
  12. Article
  13. Article
  14. Epithelial NaComprehensive Physiology · 2024
    Review
  15. The Role of Ion-Transporting Proteins in Human Disease.International journal of molecular sciences · 2024
    Article
  16. Article
  17. Review
  18. The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023
    Review
  19. Vascular mechanotransduction.Physiological reviews · 2023
    Review
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Thomas R KleymanDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA; email: kleyman@pitt.edu.
Ossama B KashlanDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA; email: kleyman@pitt.edu.
Rebecca P HugheyDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA; email: kleyman@pitt.edu.
University of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Regulation of K and H secretion by intercalated cellsR01DK038470 · NIDDK · YESHIVA UNIVERSITY · PI HUGHEY, REBECCA P, KLEYMAN, THOMAS R · 1994 to 2022
$7.7M
Allosteric ENaC RegulationR01DK098204 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KASHLAN, OSSAMA B · 2014 to 2018
$1.7M
NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK038470NIDDK NIH HHS R01 DK098204
6 · The paper itself

Abstract

Epithelial Na

Indexed as

AnimalsBiological TransportCell MembraneEpithelial Sodium ChannelsHumansLipoylationStress, PhysiologicalEpithelial Sodium ChannelsENaCpalmitoylationpalmitoyltransferaseproteaseshear stresssodium self-inhibition

Identifiers

PMID29120692
PMCPMC5811403
OpenAlexW2614256117

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.