Evidence map›Paper›PMID 29120648›Full record

ArticleNano letters2017

The Role of Nanoparticle Design in Determining Analytical Performance of Lateral Flow Immunoassays.

Li Zhan, Shuang-Zhuang Guo, Fayi Song, Yan Gong, Feng Xu, David R Boulware, Michael C McAlpine, Warren C W Chan, John C Bischof

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nano letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Li ZhanDepartment of Mechanical Engineering, University of Minnesota , 111 Church Street SE, Minneapolis, Minnesota 55455, United States.
Shuang-Zhuang GuoDepartment of Mechanical Engineering, University of Minnesota , 111 Church Street SE, Minneapolis, Minnesota 55455, United States.
Fayi SongInstitution of Biomaterials and Biomedical Engineering & Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto , 160 College Street, Toronto, Ontario 3E1, Canada.
Yan GongThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University , Xi'an 710049, China.
Feng XuThe Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University , Xi'an 710049, China.ORCID 0000-0003-4351-0222
David R BoulwareDepartment of Medicine, Microbiology Research Facility (MRF), University of Minnesota , 689 SE 23rd Avenue, Minneapolis, Minnesota 55455, United States.
Michael C McAlpineDepartment of Mechanical Engineering, University of Minnesota , 111 Church Street SE, Minneapolis, Minnesota 55455, United States.
Warren C W ChanInstitution of Biomaterials and Biomedical Engineering & Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto , 160 College Street, Toronto, Ontario 3E1, Canada.ORCID 0000-0001-5435-4785
John C BischofDepartment of Mechanical Engineering, University of Minnesota , 111 Church Street SE, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-6726-7111

Funding

Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related MeningitisR01NS086312 · NINDS · UNIVERSITY OF MINNESOTA · PI David R Boulware, David Bisagaya Meya · 2013 to 2026
$8.3M
3D Printed Nano-Bionic OrgansDP2EB020537 · NIBIB · UNIVERSITY OF MINNESOTA · PI MCALPINE, MICHAEL · 2014 to 2019
$2.7M
NIBIB NIH HHS DP2 EB020537NINDS NIH HHS R01 NS086312
6 · The paper itself

Abstract

Rapid, simple, and cost-effective diagnostics are needed to improve healthcare at the point of care (POC). However, the most widely used POC diagnostic, the lateral flow immunoassay (LFA), is ∼1000-times less sensitive and has a smaller analytical range than laboratory tests, requiring a confirmatory test to establish truly negative results. Here, a rational and systematic strategy is used to design the LFA contrast label (i.e., gold nanoparticles) to improve the analytical sensitivity, analytical detection range, and antigen quantification of LFAs. Specifically, we discovered that the size (30, 60, or 100 nm) of the gold nanoparticles is a main contributor to the LFA analytical performance through both the degree of receptor interaction and the ultimate visual or thermal contrast signals. Using the optimal LFA design, we demonstrated the ability to improve the analytical sensitivity by 256-fold and expand the analytical detection range from 3 log

Indexed as

AntibodiesC-Reactive ProteinDiffusionGoldHumansImmunoassayInflammationKineticsLimit of DetectionMetal NanoparticlesParticle SizePoint-of-Care TestingTemperatureAntibodiesC-Reactive ProteinGoldC-reactive proteinGold nanoparticlesimmunoassaysize dependentthermal contrast

Identifiers

PMID29120648
PMCPMC5747258

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.