Evidence map›Paper›PMID 29120399›Full record

ArticleGenes2017

A Microbiomic Analysis in African Americans with Colonic Lesions Reveals Streptococcus sp.VT162 as a Marker of Neoplastic Transformation.

Hassan Brim, Shibu Yooseph, Edward Lee, Zaki A Sherif, Muneer Abbas, Adeyinka O Laiyemo, Sudhir Varma, Manolito Torralba, Scot E Dowd, Karen E Nelson and 7 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Dietary supplementation ofAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2020
    Article
  11. Article
  12. WMicrobiome · 2019
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Hassan BrimDepartment of Pathology and Department of Medicine, Microbiology and Cancer Center, College of Medicine, Howard University, 2041 Georgia Avenue, Washington, DC 20060, USA. hbrim@howard.edu.
Shibu YoosephJ. Craig Venter Institute, La Jolla, CA 92037, USA. syooseph@jcvi.org.
Edward LeeDepartment of Pathology and Department of Medicine, Microbiology and Cancer Center, College of Medicine, Howard University, 2041 Georgia Avenue, Washington, DC 20060, USA. ellee@howard.edu.
Zaki A SherifDepartment of Pathology and Department of Medicine, Microbiology and Cancer Center, College of Medicine, Howard University, 2041 Georgia Avenue, Washington, DC 20060, USA. zaki.sherif@howard.edu.
Muneer AbbasDepartment of Pathology and Department of Medicine, Microbiology and Cancer Center, College of Medicine, Howard University, 2041 Georgia Avenue, Washington, DC 20060, USA. m_abbas@howard.edu.
Adeyinka O LaiyemoDepartment of Pathology and Department of Medicine, Microbiology and Cancer Center, College of Medicine, Howard University, 2041 Georgia Avenue, Washington, DC 20060, USA. adeyinka.laiyemo@howard.edu.
Sudhir VarmaHiThru Analytics, Laurel, MD 20877, USA. sudhir.varma@hithru.com.
Manolito TorralbaJ. Craig Venter Institute, La Jolla, CA 92037, USA. mtorralba@jcvi.org.
Scot E DowdMRDNA/Molecular Research LP, Shallowater, TX 79363, USA. sdowd@mrdnalab.com.
Karen E NelsonJ. Craig Venter Institute, Rockville, MD 20850, USA. knelson@jcvi.org.
Wimal PathmasiriSystems and Translational Sciences, RTI International, NC 27709, USA. wpathmasiri@rti.org.
Susan SumnerSystems and Translational Sciences, RTI International, NC 27709, USA. ssumner@rti.org.
Willem de VosLaboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, 6708 PB Wageningen, The Netherlands. willem.devos@wur.nl.
Qiaoyi LiangInstitute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. JessieQY@cuhk.edu.hk.
Jun YuInstitute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China. junyu@cuhk.edu.hk.
Erwin ZoetendalLaboratory of Microbiology, Department of Agrotechnology and Food Sciences, Wageningen University, 6708 PB Wageningen, The Netherlands. erwin.zoetendal@wur.nl.
Hassan AshktorabDepartment of Pathology and Department of Medicine, Microbiology and Cancer Center, College of Medicine, Howard University, 2041 Georgia Avenue, Washington, DC 20060, USA. hashktorab@howard.edu.
Howard University · USJ. Craig Venter Institute · USChinese University of Hong Kong, Shenzhen · CNRTI International · USWageningen University & Research · NLMassanutten Regional Library · US

Funding

Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Sleep Disorders in Adults with Sickle Cell Disease: Frequency, Associations with Cardiovascular and Pain Indicators, and Responses to TreatmentU54MD007597 · NIMHD · HOWARD UNIVERSITY · PI Tatiana V.D. Sanses · 2019 to 2026
$37.7M
Georgetown-Howard Universities Center for Clinical and Translational Science (GHUUL1TR000101 · NCATS · GEORGETOWN UNIVERSITY · PI MELLMAN, THOMAS A, VERBALIS, JOSEPH G · 2012 to 2015
$19.3M
PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
Institutional Career Development CoreKL2TR001432 · NCATS · GEORGETOWN UNIVERSITY · PI UMANS, JASON G · 2015 to 2024
$7.5M
NCATS NIH HHS KL2 TR001432NCATS NIH HHS UL1 TR000101NCATS NIH HHS UL1 TR001409NIMHD NIH HHS G12 MD007597NIMHD NIH HHS U54 MD007597
6 · The paper itself

Abstract

Increasing evidence suggests a role of the gut microbiota in colorectal carcinogenesis (CRC). To detect bacterial markers of colorectal cancer in African Americans a metabolomic analysis was performed on fecal water extracts. DNA from stool samples of adenoma and healthy subjects and from colon cancer and matched normal tissues was analyzed to determine the microbiota composition (using 16S rDNA) and genomic content (metagenomics). Metagenomic functions with discriminative power between healthy and neoplastic specimens were established. Quantitative Polymerase Chain Reaction (q-PCR) using primers and probes specific to

Indexed as

African Americanscolorectal cancermetabolomicsmetagenomic linkage groupsmicrobiota

Identifiers

PMID29120399
PMCPMC5704227
OpenAlexW2767294813

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.